HuLPr44921

Uniprot ID

RTL1_HUMAN

Uniprot Acc

A6NKG5;

Protein name

Retrotransposon-like protein 1

Comment

FUNCTION:Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta (By similarity).||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein (Potential).||MISCELLANEOUS:Rtl1 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes.||MISCELLANEOUS:RTL1 is an imprinted gene located in a cluster of imprinted genes on chromosome 14. It is expressed from the paternal chromosome and has an antisense transcript with full complementarity to RTL1, RTL1as, expressed from the maternal chromosome, which acts as a repressor for RTL1. Excessive RTL1 expression and decreased RTL1 expression are relevant to upd(14)pat-like and upd(14)mat-like phenotypes, respectively. Paternal and maternal uniparental disomy for chromosome 14 (upd(14)pat and upd(14)mat) cause distinct ph

Subcellular localization

Membrane;Multi-pass membrane protein(Potential).

Gene name

retrotransposon-like 1

Protein sequence

MIEPSEDSFETMMEHKNPSSKQMESSEGSSNTTEATSGSG VRGEAGPASGPAQEKKEPPSGPLQEMEELPTDLLQDMEE PSSGPRKEIEDPPNDLLQDLEESCNGSHQARGDPLSGAS DRMKEASVNPSGAREEQEAHTDLKESGREETPQEEQNQT EHSTAELMAMVRSIISLYFRMQDLKEQQRVAEEILIKGI NAGQLPAPKHFSGDRREFHEFIVLCQLTLQSYPRMFYND RLRVGYVINHLSGLALEWAKALLQENSPLIGDFPAFLEA MSEVFEYRQALRVAEEAMFTIRQGGRSATEYIDEFQSLV PILGWPDEVLQAHLCQGLNEEIRHYLFRVPQPDSLDSLI VLILQIEEKLAERRAMLRLPPEARPRNLTWIDSPAPERW MVSSWLPSEVHPDINRAHLFLLLMVRVNPYHSVAVQALV DSGADGNFMDEKFAQEHYVELYEKPYPQPVQSVDGSLIG NEPVWLYTEPLVCIHQNHQESIEFDIVPSPNFSVVLGIR WLRVHAPEVDWIKGRCTFHSPYCLKNCFRPPPPCIALER HGMSLLPGLPHPYSDLADVFNPKEADDETSDQPSSDGSD DLSESEPSELQQAGDSDHSETFYECPSTAPWEPVGARMQ ERARLQEEYWDLQDMLTNRQDYIQMIPELFDQLHGAEWF TKLELRGTIVEESVNGHRTEDVWKAAFGLELEEMKSYQP FALSPDPIIPQNVIHFILKDMLGFFVLSYGQEVLIYSMS QEEHLHHVRQVLVRFRHHNVYCSLDKSQFHRQTVEFLGF VVTPKGVKLNKNVMTIITGYPTPGSKLSLRNFIEFVFPY RHFVERFSIIAEPLVRQLLSSYQFYWGVEEQEAFECLKR AFRKAPLLHHPKPQNPFYLETGVTGTALHASLIQIDDQT GKRACCAFYSRNISPIEVEYSQAEMKILPIRAAFMVWCR YLENTEEPIMILLNTEDLASLNNDRLTVLLPGHWVFFFS HFNFDVMELPEQDGGRALPPVRNL

Database cross reference

RefSeq Protein accession:NP_001128360
RefSeq Protein gi:199562283

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-P

GO:0007275;P:multicellular organismal development;IEA:UniProtKB-KW.