Protein basic information
| LiverAtlas Protein ID |
HuLPr44997 |
|
Uniprot ID |
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Uniprot Acc |
Q8N1F8;Q8NAW9;Q8WXE4;Q96CN3;Q96PY9; |
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Protein name |
Serine/threonine-protein kinase 11-interacting protein |
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Comment |
FUNCTION:May regulate STK11 function by controlling its subcellular localization.||SUBUNIT:Found in a ternary complex composed of STK11, STK11IP and SMAD4. Interacts with STK11 and SMAD4.||SUBCELLULAR LOCATION:Cytoplasm. Note=Some cells show granular or punctuate expression. Colocalizes with STK11 and SMAD4 in granular or punctuate structures.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N1F8-1; Sequence=Displayed; Name=2; IsoId=Q8N1F8-2; Sequence=VSP 030969, VSP 030970;||MISCELLANEOUS:This gene contains a polymorphic substitution resulting in a variant amino acid from Met-1 to Arg-1 compared to the official human genome. However, this variant sequence is in agreement with EST and mRNA sequences.||SIMILARITY:Belongs to the STK11IP family.||SIMILARITY:Contains 8 LRR (leucine-rich) repeats.||CAUTION:It is uncertain whether Met-1 or Met-12 is the initiator. |
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Subcellular localization |
Cytoplasm. |
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Gene name |
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Protein sequence
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MFGSAPQRPVAMTTAQRDSLLWKLAGLLRESGDVVLSGCS TLSLLTPTLQQLNHVFELHLGPWGPGQTGFVALPSHPAD SPVILQLQFLFDVLQKTLSLKLVHVAGPGPTGPIKIFPF KSLRHLELRGVPLHCLHGLRGIYSQLETLICSRSLQALE ELLSACGGDFCSALPWLALLSANFSYNALTALDSSLRLL SALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLV PRMGPSGAALGVLILRGNELRSLHGLEQLRNLRHLDLAY NLLEGHRELSPLWLLAELRKLYLEGNPLWFHPEHRAATA QYLSPRARDAATGFLLDGKVLSLTDFQTHTSLGLSPMGP PLPWPVGSTPETSGGPDLSDSLSSGGVVTQPLLHKVKSR VRVRRASISEPSDTDPEPRTLNPSPAGWFVQQHPELELM SSFRERFGRNWLQYRSHLEPSGNPLPATPTTSAPSAPPA SSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEE EEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKEVEAE LCRPLLVCPLEGPEGVRGRECFLRVTSAHLFEVELQAAR TLERLELQSLEAAEIEPEAQAQRSPRPTGSDLLPGAPIL SLRFSYICPDRQLRRYLVLEPDAHAAVQELLAVLTPVTN VAREQLGEARDLLLGRFQCLRCGHEFKPEEPRMGLDSEE GWRPLFQKTESPAVCPNCGSDHVVLLAVSRGTPNRERKQ GEQSLAPSPSASPVCHPPGHGDHLDRAKNSPPQAPSTRD HGSWSLSPPPERCGLRSVDHRLRLFLDVEVFSDAQEEFQ CCLKVPVALAGHTGEFMCLVVVSDRRLYLLKVTGEMREP PASWLQLTLAVPLQDLSGIELGLAGQSLRLEWAAGAGRC VLLPRDARHCRAFLEELLDVLQSLPPAWRNCVSATEEEV TPQHRLWPLLEKDSSLEARQFFYLRAFLVEGPSTCLVSL LLTPSTLFLLDEDAAGSPAEPSPP |
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Database cross reference |
RefSeq Protein accession:NP_443134
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IDA:UniProtKB. |
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GO-F |
GO:0019901;F:protein kinase binding;IPI:UniProtKB. |
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GO-P |
GO:0008104;P:protein localization;IDA:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr44997 |
PHOSPHORYLATION |
398 |
S |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr44997 |
PHOSPHORYLATION |
400 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr44997 |
PHOSPHORYLATION |
403 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr44997 |
PHOSPHORYLATION |
772 |
S |
PhosphoSitePlus |
LTP HTP |
yes |
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Pathway
| Pathway name |
