HuLPr45004

Uniprot ID

S12A7_HUMAN

Uniprot Acc

Q9Y666;A6NDS8;Q4G0F3;Q96I81;Q9H7I3;Q9H7I7;Q9UFW2;

Protein name

Solute carrier family 12 member 7

Comment

FUNCTION:Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).||ENZYME REGULATION:Activated by N-ethylmaleimide (NEM). Inhibited by furosemide, DIDS and bumetanide. The inhibition is much stronger in the presence of 50 mM K(+) in the uptake medium. Inhibited by DIOA.||SUBUNIT:Homomultimer and heteromultimer with other K-Cl cotransporters (By similarity).||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y666-1; Sequence=Displayed; Name=2; IsoId=Q9Y666-2; Sequence=VSP 006119, VSP 006120; Note=No experimental confirmation ava

Subcellular localization

Membrane;Multi-pass membrane protein.

Gene name

solute carrier family 12 (potassium/chloride transporters), member 7

Protein sequence

MPTNFTVVPVEAHADGGGDETAERTEAPGTPEGPEPERPS PGDGNPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSN PMVSSLLNKLANYTNLSQGVVEHEEDEESRRREAKAPRM GTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIV AMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPE FGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIF QAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVN KLALVFLACVVLSILAIYAGVIKSAFDPPDIPVCLLGNR TLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQPSAAC DEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVE KKGVPSVPVAEESRASALPYVLTDIAASFTLLVGIYFPS VTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSC IVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIV IGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGH GKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFL MCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSL CLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDG IRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAE QAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEA QRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSA GLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDTTA AHQALLVAKNVDSFPQNQERFGGGHIDVWWIVHDGGMLM LLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMF LYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLK QMQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPTPDK VQMTWTREKLIAEKYRSRDTSLSG

Database cross reference

RefSeq Protein accession:NP_006589
RefSeq Protein gi:123701900

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005887;C:integral to plasma membrane;TAS:ProtInc.

GO-F

GO:0015379;F:potassium:chloride symporter activity;TAS:Reactome.

GO-P

GO:0006813;P:potassium ion transport;IEA:UniProtKB-KW. GO:0006814;P:sodium ion transport;IEA:InterPro.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr45004

PHOSPHORYLATION

30

T

Phospho-ELM

40543

HTP

N

HuLPr45004

PHOSPHORYLATION

40

S

Phospho-ELM

40540

HTP

N

HuLPr45004

PHOSPHORYLATION

50

S

Phospho-ELM

40541

HTP

N

HuLPr45004

PHOSPHORYLATION

62

S

Phospho-ELM

40542

HTP

N

HuLPr45004

PHOSPHORYLATION

92

Y

PhosphoSitePlus

474153

LTP

N

HuLPr45004

PHOSPHORYLATION

991

Y

PhosphoSitePlus

460288

LTP

HTP

N

HuLPr45004

PHOSPHORYLATION

926

T

PhosphoSitePlus

12738728

LTP

N

HuLPr45004

PHOSPHORYLATION

973

T

PhosphoSitePlus

4786481

HTP

N

HuLPr45004

PHOSPHORYLATION

980

T

PhosphoSitePlus

4786486

LTP

N

HuLPr45004

PHOSPHORYLATION

997

S

PhosphoSitePlus

4836905

LTP

N

HuLPr45004

PHOSPHORYLATION

50

S

PhosphoSitePlus

468760

HTP

N

HuLPr45004

PHOSPHORYLATION

40

S

PhosphoSitePlus

3217701

HTP

N

HuLPr45004

PHOSPHORYLATION

62

S

PhosphoSitePlus

3217704

HTP

N

HuLPr45004

PHOSPHORYLATION

996

T

PhosphoSitePlus

5207784

HTP

N

HuLPr45004

PHOSPHORYLATION

30

T

PhosphoSitePlus

477871

HTP

N