Protein basic information
| LiverAtlas Protein ID |
HuLPr45029 |
|
Uniprot ID |
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Uniprot Acc |
P21453;D3DT66;Q9BYY4;Q9NYN8; |
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Protein name |
Sphingosine 1-phosphate receptor 1 |
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Comment |
FUNCTION:Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins.||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein.||TISSUE SPECIFICITY:Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.||INDUCTION:By the tumor promoter phorbol 12-myristate 13-acetate (PMA) in the presence of cycloheximide.||PTM:S1P-induced endothelial cell migration requires the PKB/AKT1- mediated phosphorylation of the third intracellular loop at the Thr-236 residue.||SIMILARITY:Belongs to the G-protein coupled receptor 1 family. |
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Subcellular localization |
Cell membrane;Multi-pass membrane protein. |
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Gene name |
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Protein sequence
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MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISAD KENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRP MYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWF LREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNN FRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLP LYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRL TFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFI LLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTL TNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSR SKSDNSSHPQKDEGDNPETIMSSGNVNSSS |
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Database cross reference |
RefSeq Protein accession:NP_001391
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
French Liver; |
Ontology annotation
| GO-C |
GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. |
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GO-F |
GO:0001619;F:lysosphingolipid and lysophosphatidic acid receptor activity;IEA:InterPro. |
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GO-P |
GO:0007155;P:cell adhesion;TAS:ProtInc. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr45029 |
PHOSPHORYLATION |
236 |
T |
Phospho-ELM |
LTP |
N |
 
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HuLPr45029 |
PHOSPHORYLATION |
236 |
T |
PhosphoSitePlus |
LTP |
N |
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Pathway
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