Protein basic information
| LiverAtlas Protein ID |
HuLPr45030 |
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Uniprot ID |
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Uniprot Acc |
Q99500;Q5SQD8;Q7Z5I2; |
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Protein name |
Sphingosine 1-phosphate receptor 3 |
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Comment |
FUNCTION:Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein.||TISSUE SPECIFICITY:Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.||SIMILARITY:Belongs to the G-protein coupled receptor 1 family. |
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Subcellular localization |
Cell membrane;Multi-pass membrane protein. |
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Gene name |
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Protein sequence
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MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGST LTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIG NLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSM FVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLL IGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKY IAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNS ERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQAC PILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLV CNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVK EDLPHTAPSSCIMDKNAALQNGIFCN |
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Database cross reference |
RefSeq Protein accession:NP_005217
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005887;C:integral to plasma membrane;TAS:ProtInc. |
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GO-F |
GO:0008289;F:lipid binding;TAS:ProtInc. GO:0001619;F:lysosphingolipid and lysophosphatidic acid receptor activity;IEA:InterPro. |
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GO-P |
GO:0009653;P:anatomical structure morphogenesis;TAS:ProtInc. GO:0007204;P:elevation of cytosolic calcium ion concentration;TAS:ProtInc. GO:0006954;P:inflammatory response;TAS:ProtInc. GO:0008284;P:positive regulation of cell proliferation;TAS:ProtInc. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr45030 |
PHOSPHORYLATION |
326 |
S |
PhosphoSitePlus |
HTP |
N |
 
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Pathway
| Pathway name | |
| Pathway name |
