Protein basic information
| LiverAtlas Protein ID |
HuLPr45031 |
|
Uniprot ID |
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Uniprot Acc |
O95977;D6W612; |
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Protein name |
Sphingosine 1-phosphate receptor 4 |
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Comment |
FUNCTION:Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein.||TISSUE SPECIFICITY:Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung.||SIMILARITY:Belongs to the G-protein coupled receptor 1 family. |
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Subcellular localization |
Cell membrane;Multi-pass membrane protein. |
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Gene name |
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Protein sequence
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MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGG PEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRR WVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQW FLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGAT KTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSL LPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQ KAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLAD VFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSRE VCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTD SSLRPRDSFRGSRSLSFRMREPLSSISSVRSI |
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Database cross reference |
RefSeq Protein accession:NP_003766
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005887;C:integral to plasma membrane;TAS:ProtInc. |
|
GO-F |
GO:0008289;F:lipid binding;TAS:ProtInc. GO:0001619;F:lysosphingolipid and lysophosphatidic acid receptor activity;IEA:InterPro. |
|
GO-P |
GO:0007202;P:activation of phospholipase C activity;TAS:ProtInc. GO:0007204;P:elevation of cytosolic calcium ion concentration;TAS:ProtInc. GO:0006955;P:immune response;TAS:ProtInc. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr45031 |
PHOSPHORYLATION |
383 |
S |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr45031 |
PHOSPHORYLATION |
380 |
S |
PhosphoSitePlus |
HTP |
N |
|
Pathway
| Pathway name | |
| Pathway name |
