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Protein basic information

LiverAtlas Protein ID

HuLPr45032

Uniprot ID

S1PR5_HUMAN

Uniprot Acc

Q9H228;Q6NW11;

Protein name

Sphingosine 1-phosphate receptor 5

Comment

FUNCTION:Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H228-1; Sequence=Displayed; Name=2; IsoId=Q9H228-2; Sequence=VSP 013369, VSP 013370;||TISSUE SPECIFICITY:Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 i

Subcellular localization

Cell membrane;Multi-pass membrane protein.

Gene name

sphingosine-1-phosphate receptor 5

Protein sequence

MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADA VVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLT LSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVA LTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAA AWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLF CVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGT TSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLD VACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDL RHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCL PPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD

Database cross reference

RefSeq Protein accession:NP_001159687
RefSeq Protein gi:261278306

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;EXP:Reactome.

GO-F

GO:0001619;F:lysosphingolipid and lysophosphatidic acid receptor activity;IEA:InterPro.

Pathway

Pathway name

Sphingosine_1-phosphate_(S1P)_pathway

Pathway name

S1P4_pathway

Pathway name

S1P5_pathway