Protein basic information
| LiverAtlas Protein ID |
HuLPr45033 |
|
Uniprot ID |
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Uniprot Acc |
Q8WUM9;Q08344;Q6DHX8;Q9UQ82; |
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Protein name |
Sodium-dependent phosphate transporter 1 |
|
Comment |
FUNCTION:Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV).||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=24.1 uM for phosphate; Vmax=1.9 nmol/min/mg enzyme (in the presence of 0.05-2 mM phosphate); Note=With an increase in pH, a decrease in phosphate uptake is observed; pH dependence: Optimum pH is 6.5 and 7.5;||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein.||TISSUE SPECIFICITY:Ubi |
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Subcellular localization |
Membrane;Multi-pass membrane protein. |
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Gene name |
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Protein sequence
|
MATLITSTTAATAASGPLVDYLWMLILGFIIAFVLAFSVG ANDVANSFGTAVGSGVVTLKQACILASIFETVGSVLLGA KVSETIRKGLIDVEMYNSTQGLLMAGSVSAMFGSAVWQL VASFLKLPISGTHCIVGATIGFSLVAKGQEGVKWSELIK IVMSWFVSPLLSGIMSGILFFLVRAFILHKADPVPNGLR ALPVFYACTVGINLFSIMYTGAPLLGFDKLPLWGTILIS VGCAVFCALIVWFFVCPRMKRKIEREIKCSPSESPLMEK KNSLKEDHEETKLSVGDIENKHPVSEVGPATVPLQAVVE ERTVSFKLGDLEEAPERERLPSVDLKEETSIDSTVNGAV QLPNGNLVQFSQAVSNQINSSGHYQYHTVHKDSGLYKEL LHKLHLAKVGDCMGDSGDKPLRRNNSYTSYTMAICGMPL DSFRAKEGEQKGEEMEKLTWPNADSKKRIRMDSYTSYCN AVSDLHSASEIDMSVKAEMGLGDRKGSNGSLEEWYDQDK PEVSLLFQFLQILTACFGSFAHGGNDVSNAIGPLVALYL VYDTGDVSSKVATPIWLLLYGGVGICVGLWVWGRRVIQT MGKDLTPITPSSGFSIELASALTVVIASNIGLPISTTHC KVGSVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPISGVISAAIMAIFRYVILRM |
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Database cross reference |
RefSeq Protein accession:NP_005406
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
French Liver; |
Ontology annotation
| GO-C |
GO:0005887;C:integral to plasma membrane;TAS:ProtInc. |
|
GO-F |
GO:0005315;F:inorganic phosphate transmembrane transporter activity;IEA:InterPro. GO:0004872;F:receptor activity;TAS:ProtInc. GO:0015321;F:sodium-dependent phosphate transmembrane transporter activity;TAS:Reactome. |
|
GO-P |
GO:0006796;P:phosphate metabolic process;TAS:ProtInc. GO:0043123;P:positive regulation of I-kappaB kinase/NF-kappaB cascade;IMP:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr45033 |
PHOSPHORYLATION |
265 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr45033 |
PHOSPHORYLATION |
269 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr45033 |
PHOSPHORYLATION |
417 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr45033 |
PHOSPHORYLATION |
463 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45033 |
PHOSPHORYLATION |
467 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr45033 |
PHOSPHORYLATION |
277 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45033 |
PHOSPHORYLATION |
465 |
T |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr45033 |
PHOSPHORYLATION |
466 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45033 |
PHOSPHORYLATION |
335 |
S |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr45033 |
PHOSPHORYLATION |
265 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr45033 |
PHOSPHORYLATION |
269 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45033 |
PHOSPHORYLATION |
464 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45033 |
PHOSPHORYLATION |
421 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45033 |
PHOSPHORYLATION |
388 |
Y |
PhosphoSitePlus |
LTP HTP |
N |
|
Pathway
| Pathway name | |
| Pathway name | |
| Pathway name |
