HuLPr45039

Uniprot ID

S22A5_HUMAN

Uniprot Acc

O76082;B2R844;D3DQ87;Q6ZQZ8;Q96EH6;

Protein name

Solute carrier family 22 member 5

Comment

FUNCTION:Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.||SUBUNIT:Interacts with PDZK1 (By similarity).||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O76082-1; Sequence=Displayed; Name=2; IsoId=O76082-2; Sequence=VSP 011120, VSP 011121; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Strongly expressed in kidney, skeletal muscle, heart and placenta. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells.||DISEASE:Defects in SLC22A5 are the cause of systemic primary carnitine d

Subcellular localization

Membrane;Multi-pass membrane protein.

Gene name

solute carrier family 22 (organic cation/carnitine transporter), member 5

Related liver disease name

Fatty liver

Protein sequence

MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSV FLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPH SCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWE FSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGS FISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMF VVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGV CIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALW WFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIF DPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWM TISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAW LLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATV LVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTA SRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLF LPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF

Database cross reference

RefSeq Protein accession:NP_003051
RefSeq Protein gi:4507005

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0016324;C:apical plasma membrane;IDA:BHF-UCL. GO:0031526;C:brush border membrane;IDA:BHF-UCL. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0015226;F:carnitine transporter activity;IDA:BHF-UCL. GO:0030165;F:PDZ domain binding;IPI:BHF-UCL. GO:0015293;F:symporter activity;IEA:UniProtKB-KW.

GO-P

GO:0060731;P:positive regulation of intestinal epithelial structure maintenance;IMP:BHF-UCL. GO:0052106;P:quorum sensing involved in interaction with host;IMP:BHF-UCL. GO:0006814;P:sodium ion transport;IEA:UniProtKB-KW. GO:0070715;P:sodium-dependent org

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr45039

PHOSPHORYLATION

486

Y

PhosphoSitePlus

14161258

LTP

N