HuLPr45070

Uniprot ID

S2547_HUMAN

Uniprot Acc

Q6Q0C1;B2RP39;Q68CL2;Q6PZD8;Q86U14;

Protein name

Solute carrier family 25 member 47

Comment

FUNCTION:Uncoupling protein which may catalyze the physiological 'proton leak' in liver. Overexpression induces the dissipation of mitochondrial membrane potential.||SUBCELLULAR LOCATION:Mitochondrion inner membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6Q0C1-1; Sequence=Displayed; Name=2; IsoId=Q6Q0C1-2; Sequence=VSP 026233, VSP 026234;||TISSUE SPECIFICITY:Specifically expressed in liver.||INDUCTION:Down-regulated in hepatocarcinoma.||SIMILARITY:Belongs to the mitochondrial carrier family.||SIMILARITY:Contains 3 Solcar repeats.||SEQUENCE CAUTION:Sequence=BAD38636.1; Type=Erroneous translation; Note=Wrong choice of frame; Sequence=CAD62588.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Subcellular localization

Mitochondrion inner membrane;Multi-pass membrane protein.

Gene name

solute carrier family 25, member 47

Protein sequence

MDFVAGAIGGVCGVAVGYPLDTVKVRIQTEPKYTGIWHCV RDTYHRERVWGFYRGLSLPVCTVSLVSSVSFGTYRHCLA HICRLRYGNPDAKPTKADITLSGCASGLVRVFLTSPTEV AKVRLQTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEP KYRGPLHCLATVAREEGLCGLYKGSSALVLRDGHSFATY FLSYAVLCEWLSPAGHSRPDVPGVLVAGGCAGVLAWAVA TPMDVIKSRLQADGQGQRRYRGLLHCMVTSVREEGPRVL FKGLVLNCCRAFPVNMVVFVAYEAVLRLARGLLT

Database cross reference

RefSeq Protein accession:NP_997000
RefSeq Protein gi:46397377

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005743;C:mitochondrial inner membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0005488;F:binding;IEA:InterPro.

GO-P

GO:0055085;P:transmembrane transport;IEA:InterPro.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr45070

PHOSPHORYLATION

127

T

PhosphoSitePlus

485393

LTP

N