HuLPr45077

Uniprot ID

S26A5_HUMAN

Uniprot Acc

P58743;Q86UF8;Q86UF9;Q86UG0;

Protein name

Prestin

Comment

FUNCTION:Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage- to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplet

Subcellular localization

Cell membrane;Multi-pass membrane protein(By similarity).

Gene name

solute carrier family 26, member 5 (prestin)

Protein sequence

MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPD SIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYKFKEY VLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFY PVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIV IPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVC RFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTK RYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLG GKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLKESY NVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFS VTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTF SISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGF LFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIEL TIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSY KVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYA NSDLYSNALKRKTGVNPAVIMGARRKAMRKYAKEVGNAN MANATVVKADAEVDGEDATKPEEEDGEVKYPPIVIKSTF PEEMQRFMPPGDNVHTVILDFTQVNFIDSVGVKTLAGIV KEYGDVGIYVYLAGCSAQVVNDLTRNRFFENPALWELLF HSIHDAVLGSQLREALAEQEASAPPSQEDLEPNATPATPEA

Database cross reference

RefSeq Protein accession:NP_001161434
RefSeq Protein gi:269784651

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0003774;F:motor activity;IEA:UniProtKB-KW. GO:0008271;F:secondary active sulfate transmembrane transporter activity;IEA:InterPro.

GO-P

GO:0008360;P:regulation of cell shape;IEA:UniProtKB-KW. GO:0007605;P:sensory perception of sound;IMP:UniProtKB.