HuLPr45103

Uniprot ID

S35B3_HUMAN

Uniprot Acc

Q9H1N7;A6NKX9;Q1XH11;Q6MZJ0;Q7Z662;Q9Y308;

Protein name

Adenosine 3'-phospho 5'-phosphosulfate transporter 2

Comment

FUNCTION:Mediates the transport of adenosine 3'-phospho 5'- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=2.2 uM for PAPS;||SUBCELLULAR LOCATION:Golgi apparatus membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9H1N7-1; Sequence=Displayed; Name=2; IsoId=Q9H1N7-2; Sequence=VSP 016193, VSP 016194; Note=No experimental confirmation available; Name=3; IsoId=Q9H1N7-3; Sequence=VSP 016195, VSP 016196; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Preferentially and highly expressed in colon.||SIMILARITY:Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.||SEQUENCE CAUTION:Sequence=AAD27728.1; Type=Frameshift; Po

Subcellular localization

Golgi apparatus membrane;Multi-pass membrane protein.

Gene name

solute carrier family 35, member B3

Protein sequence

MDLTQQAKDIQNITVQETNKNNSESIECSKITMDLKFNNS RKYISITVPSKTQTMSPHIKSVDDVVVLGMNLSKFNKLT QFFICVAGVFVFYLIYGYLQELIFSVEGFKSCGWYLTLV QFAFYSIFGLIELQLIQDKRRRIPGKTYMIIAFLTVGTM GLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQGKRYN VADVSAAICMSLGLIWFTLADSTTAPNFNLTGVVLISLA LCADAVIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILL GLTCTSGLGPAVTFCAKNPVRTYGYAFLFSLTGYFGISF VLALIKIFGALIAVTVTTGRKAMTIVLSFIFFAKPFTFQ YVWSGLLVVLGIFLNVYSKNMDKIRLPSLYDLINKSVEA RKSRTLAQTV

Database cross reference

RefSeq Protein accession:NP_001136012
RefSeq Protein gi:216547920

GO:0000139;C:Golgi membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-P

GO:0055085;P:transmembrane transport;IEA:InterPro.