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Protein basic information

LiverAtlas Protein ID

HuLPr45106

Uniprot ID

S35D1_HUMAN

Uniprot Acc

Q9NTN3;A8K185;Q52LU5;Q92548;

Protein name

UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter

Comment

FUNCTION:Transports both UDP-glucuronic acid (UDP-GlcA) and UDP- N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm to into the endoplasmic reticulum lumen. May participate in glucuronidation and/or chondroitin sulfate biosynthesis.||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Multi-pass membrane protein.||TISSUE SPECIFICITY:Ubiquitous.||DISEASE:Defects in SLC35D1 are a cause of Schneckenbecken dysplasia (SCHBCKD) [MIM:269250]. Schneckenbecken dysplagia is a rare, autosomal recessive, lethal short-limbed skeletal dysplasia with platyspondylia.||SIMILARITY:Belongs to the TPT transporter family. SLC35D subfamily.||SEQUENCE CAUTION:Sequence=BAA13390.1; Type=Erroneous initiation;||WEB RESOURCE:Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/";

Subcellular localization

Endoplasmic reticulum membrane;Multi-pass membrane protein.

Gene name

solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1

Protein sequence

MAEVHRRQHARVKGEAPAKSSTLRDEEELGMASAETLTVF LKLLAAGFYGVSSFLIVVVNKSVLTNYRFPSSLCVGLGQ MVATVAVLWVGKALRVVKFPDLDRNVPRKTFPLPLLYFG NQITGLFSTKKLNLPMFTVLRRFSILFTMFAEGVLLKKT FSWGIKMTVFAMIIGAFVAASSDLAFDLEGYAFILINDV LTAANGAYVKQKLDSKELGKYGLLYYNALFMILPTLAIA YFTGDAQKAVEFEGWADTLFLLQFTLSCVMGFILMYATV LCTQYNSALTTTIVGCIKNILITYIGMVFGGDYIFTWTN FIGLNISIAGSLVYSYITFTEEQLSKQSEANNKLDIKGKGAV

Database cross reference

RefSeq Protein accession:NP_055954
RefSeq Protein gi:14028875

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0030176;C:integral to endoplasmic reticulum membrane;NAS:UniProtKB.

GO-F

GO:0005461;F:UDP-glucuronic acid transmembrane transporter activity;EXP:Reactome. GO:0005463;F:UDP-N-acetylgalactosamine transmembrane transporter activity;NAS:UniProtKB.

GO-P

GO:0030206;P:chondroitin sulfate biosynthetic process;NAS:UniProtKB. GO:0006065;P:UDP-glucuronate biosynthetic process;EXP:Reactome. GO:0006805;P:xenobiotic metabolic process;TAS:Reactome.