HuLPr45107

Uniprot ID

S35D2_HUMAN

Uniprot Acc

Q76EJ3;O95454;Q498C1;Q75W21;Q7Z5X5;

Protein name

UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter

Comment

FUNCTION:Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP- mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=8 uM for UDP-N-acetylglucosamine; KM=2.1 uM for UDP-glucose; KM=0.14 uM for GDP-mannose;||SUBCELLULAR LOCATION:Golgi apparatus membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q76EJ3-1; Sequence=Displayed; Name=2; IsoId=Q76EJ3-2; Sequence=VSP 030006; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Highly expressed in heart, kidney, small intestine, placenta, lung and peripheral blood leukocyte. Weakly

Subcellular localization

Golgi apparatus membrane;Multi-pass membrane protein.

Gene name

solute carrier family 35, member D2

Protein sequence

MTAGGQAEAEGAGGEPGAARLPSRVARLLSALFYGTCSFL IVLVNKALLTTYGFPSPIFLGIGQMAATIMILYVSKLNK IIHFPDFDKKIPVKLFPLPLLYVGNHISGLSSTSKLSLP MFTVLRKFTIPLTLLLETIILGKQYSLNIILSVFAIILG AFIAAGSDLAFNLEGYIFVFLNDIFTAANGVYTKQKMDP KELGKYGVLFYNACFMIIPTLIISVSTGDLQQATEFNQW KNVVFILQFLLSCFLGFLLMYSTVLCSYYNSALTTAVVG AIKNVSVAYIGILIGGDYIFSLLNFVGLNICMAGGLRYS FLTLSSQLKPKPVGEENICLDLKS

Database cross reference

RefSeq Protein accession:NP_008932
RefSeq Protein gi:223029426

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0000139;C:Golgi membrane;TAS:Reactome. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0005338;F:nucleotide-sugar transmembrane transporter activity;NAS:UniProtKB.