HuLPr45118

Uniprot ID

S36A1_HUMAN

Uniprot Acc

Q7Z2H8;Q7Z7C0;Q96M74;

Protein name

Proton-coupled amino acid transporter 1

Comment

FUNCTION:Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity).||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein (By similarity). Lysosome membrane; Multi-pass membrane protein.||SIMILARITY:Belongs to the amino acid/polyamine transporter 2 family.||SEQUENCE CAUTION:Sequence=BAB71435.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;

Subcellular localization

Cell membrane;Multi-pass membrane protein(By similarity).Lysosome membrane;Multi-pass membrane protein.

Gene name

solute carrier family 36 (proton/amino acid symporter), member 1

Protein sequence

MSTQRLRNEDYHDYSSTDVSPEESPSEGLNNLSSPGSYQR FGQSNSTTWFQTLIHLLKGNIGTGLLGLPLAVKNAGIVM GPISLLIIGIVAVHCMGILVKCAHHFCRRLNKSFVDYGD TVMYGLESSPCSWLRNHAHWGRRVVDFFLIVTQLGFCCV YFVFLADNFKQVIEAANGTTNNCHNNETVILTPTMDSRL YMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMI YQFIVQRIPDPSHLPLVAPWKTYPLFFGTAIFSFEGIGM VLPLENKMKDPRKFPLILYLGMVIVTILYISLGCLGYLQ FGANIQGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFY VPAEIIIPFFVSRAPEHCELVVDLFVRTVLVCLTCILAI LIPRLDLVISLVGSVSSSALALIIPPLLEVTTFYSEGMS PLTIFKDALISILGFVGFVVGTYEALYELIQPSNAPIFINSTCAFI

Database cross reference

RefSeq Protein accession:NP_510968
RefSeq Protein gi:41352721

GO:0005783;C:endoplasmic reticulum;IDA:LIFEdb. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005765;C:lysosomal membrane;IEA:UniProtKB-SubCell. GO:0005886;C:plasma membrane;EXP:Reactome.

GO-F

GO:0015171;F:amino acid transmembrane transporter activity;EXP:Reactome. GO:0015293;F:symporter activity;IEA:UniProtKB-KW.

GO-P

GO:0034641;P:cellular nitrogen compound metabolic process;TAS:Reactome. GO:0006811;P:ion transport;TAS:Reactome.