Protein basic information
| LiverAtlas Protein ID |
HuLPr45122 |
|
Uniprot ID |
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|
Uniprot Acc |
Q96QD8;Q6IA88;Q6ZMG2;Q9HAV3;Q9NVA8;Q9P2G5; |
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Protein name |
Sodium-coupled neutral amino acid transporter 2 |
|
Comment |
FUNCTION:Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta.||ENZYME REGULATION:Inhibited by N-methyl-D-glucamine and probably choline.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=0.39 mM for 2-methylamino-isobutyric acid (MeAIB) (at pH 8.0);||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96QD8-1; Sequence=Displayed; Name=2; |
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Subcellular localization |
Cell membrane;Multi-pass membrane protein. |
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Gene name |
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Protein sequence
|
MKKAEMGRFSISPDEDSSSYSSNSDFNYSYPTKQAALKSH YADVDPENQNFLLESNLGKKKYETEFHPGTTSFGMSVFN LSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYS VHLLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQ NIGAMSSYLFIVKYELPLVIQALTNIEDKTGLWYLNGNY LVLLVSLVVILPLSLFRNLGYLGYTSGLSLLCMVFFLIV VICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHN VTENDSCRPHYFIFNSQTVYAVPILIFSFVCHPAVLPIY EELKDRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYE HVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVI FPIRSSVTHLLCASKDFSWWRHSLITVSILAFTNLLVIF VPTIRDIFGFIGASAASMLIFILPSAFYIKLVKKEPMKS VQKIGALFFLLSGVLVMTGSMALIVLDWVHNAPGGGH |
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Database cross reference |
RefSeq Protein accession:NP_061849
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Ontology annotation
| GO-C |
GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;EXP:Reactome. |
|
GO-F |
GO:0015171;F:amino acid transmembrane transporter activity;EXP:Reactome. GO:0015293;F:symporter activity;IEA:UniProtKB-KW. |
|
GO-P |
GO:0034641;P:cellular nitrogen compound metabolic process;TAS:Reactome. GO:0014047;P:glutamate secretion;TAS:Reactome. GO:0007269;P:neurotransmitter secretion;TAS:Reactome. GO:0006814;P:sodium ion transport;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr45122 |
PHOSPHORYLATION |
41 |
Y |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr45122 |
PHOSPHORYLATION |
28 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr45122 |
PHOSPHORYLATION |
10 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45122 |
PHOSPHORYLATION |
12 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45122 |
PHOSPHORYLATION |
17 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45122 |
PHOSPHORYLATION |
18 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45122 |
PHOSPHORYLATION |
19 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45122 |
PHOSPHORYLATION |
21 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45122 |
PHOSPHORYLATION |
22 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45122 |
PHOSPHORYLATION |
469 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr45122 |
PHOSPHORYLATION |
20 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45122 |
PHOSPHORYLATION |
30 |
Y |
PhosphoSitePlus |
LTP |
N |
|
Pathway
| Pathway name |
