HuLPr45124

Uniprot ID

S38A4_HUMAN

Uniprot Acc

Q969I6;A8K553;

Protein name

Sodium-coupled neutral amino acid transporter 4

Comment

FUNCTION:Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5.||BIOPHYSICOCHEMICAL PROPERTIES:pH dependence: Optimum pH is 7.5-8.5;||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein.||TISSUE SPECIFICITY:Detected in embryonic and adult liver, and at lower levels in adult muscle, kidney and pancreas. Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels.||SIMILARITY:Belongs to the amino acid/polyamine transporter 2 family.

Subcellular localization

Cell membrane;Multi-pass membrane protein.

Gene name

solute carrier family 38, member 4

Protein sequence

MDPMELRNVNIEPDDESSSGESAPDSYIGIGNSEKAAMSS QFANEDTESQKFLTNGFLGKKKLADYADEHHPGTTSFGM SSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAIL SLYSVHLLLKTAKEGGSLIYEKLGEKAFGWPGKIGAFVS ITMQNIGAMSSYLFIIKYELPEVIRAFMGLEENTGEWYL NGNYLIIFVSVGIILPLSLLKNLGYLGYTSGFSLTCMVF FVSVVIYKKFQIPCPLPVLDHSVGNLSFNNTLPMHVVML PNNSESSDVNFMMDYTHRNPAGLDENQAKGSLHDSGVEY EAHSDDKCEPKYFVFNSRTAYAIPILVFAFVCHPEVLPI YSELKDRSRRKMQTVSNISITGMLVMYLLAALFGYLTFY GEVEDELLHAYSKVYTLDIPLLMVRLAVLVAVTLTVPIV LFPIRTSVITLLFPKRPFSWIRHFLIAAVLIALNNVLVI LVPTIKYIFGFIGASSATMLIFILPAVFYLKLVKKETFR SPQKVGALIFLVVGIFFMIGSMALIIIDWIYDPPNSKHH

Database cross reference

RefSeq Protein accession:NP_001137296
RefSeq Protein gi:219689132

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;EXP:Reactome.

GO-F

GO:0015171;F:amino acid transmembrane transporter activity;EXP:Reactome. GO:0015293;F:symporter activity;IEA:UniProtKB-KW.

GO-P

GO:0034641;P:cellular nitrogen compound metabolic process;TAS:Reactome. GO:0006814;P:sodium ion transport;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr45124

PHOSPHORYLATION

49

S

PhosphoSitePlus

484491

LTP

HTP

N