Protein basic information
| LiverAtlas Protein ID |
HuLPr45135 |
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Uniprot ID |
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Uniprot Acc |
Q13433;B4DR49;B4E224;Q8IXR3;Q96HP5; |
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Protein name |
Zinc transporter ZIP6 |
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Comment |
FUNCTION:May act as a zinc-influx transporter.||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13433-1; Sequence=Displayed; Name=2; IsoId=Q13433-2; Sequence=VSP 014309, VSP 014310, VSP 014311; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma.||INDUCTION:Up-regulated by estrogen in breast cancer cells lines.||PTM:N-glycosylated.||SIMILARITY:Belongs to the ZIP transporter (TC 2.A.5) family.||SEQUENCE CAUTION:Sequence=BAG61161.1; Type=Erroneous initiation; |
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Subcellular localization |
Cell membrane;Multi-pass membrane protein. |
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Gene name |
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Protein sequence
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MARKLSVILILTFALSVTNPLHELKAAAFPQTTEKISPNW ESGINVDLAISTRQYHLQQLFYRYGENNSLSVEGFRKLL QNIGIDKIKRIHIHHDHDHHSDHEHHSDHERHSDHEHHS EHEHHSDHDHHSHHNHAASGKNKRKALCPDHDSDSSGKD PRNSQGKGAHRPEHASGRRNVKDSVSASEVTSTVYNTVS EGTHFLETIETPRPGKLFPKDVSSSTPPSVTSKSRVSRL AGRKTNESVSEPRKGFMYSRNTNENPQECFNASKLLTSH GMGIQVPLNATEFNYLCPAIINQIDARSCLIHTSEKKAE IPPKTYSLQIAWVGGFIAISIISFLSLLGVILVPLMNRV FFKFLLSFLVALAVGTLSGDAFLHLLPHSHASHHHSHSH EEPAMEMKRGPLFSHLSSQNIEESAYFDSTWKGLTALGG LYFMFLVEHVLTLIKQFKDKKKKNQKKPENDDDVEIKKQ LSKYESQLSTNEEKVDTDDRTEGYLRADSQEPSHFDSQQ PAVLEEEEVMIAHAHPQEVYNEYVPRGCKNKCHSHFHDT LGQSDDLIHHHHDYHHILHHHHHQNHHPHSHSQRYSREE LKDAGVATLAWMVIMGDGLHNFSDGLAIGAAFTEGLSSG LSTSVAVFCHELPHELGDFAVLLKAGMTVKQAVLYNALS AMLAYLGMATGIFIGHYAENVSMWIFALTAGLFMYVALV DMVPEMLHNDASDHGCSRWGYFFLQNAGMLLGFGIMLLISIFEHKIVFRINF |
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Database cross reference |
RefSeq Protein accession:NP_001092876
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0031258;C:lamellipodium membrane;IDA:UniProtKB. |
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GO-F |
GO:0005385;F:zinc ion transmembrane transporter activity;TAS:Reactome. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr45135 |
PHOSPHORYLATION |
478 |
S |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr45135 |
PHOSPHORYLATION |
528 |
Y |
PhosphoSitePlus |
LTP |
N |
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