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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr45137

Uniprot ID

S39A8_HUMAN

Uniprot Acc

Q9C0K1;Q96SM9;Q9BVC0;Q9NSA4;

Protein name

Zinc transporter ZIP8

Comment

FUNCTION:Acts as a zinc-influx transporter.||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein (Potential). Note=Associated with the lysosomal/endosomal compartment following transfection.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9C0K1-1; Sequence=Displayed; Name=2; IsoId=Q9C0K1-2; Sequence=VSP 029884, VSP 029885; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas.||INDUCTION:By live and heat-killed Mycobacterium bovis bacterial cell wall and inflammatory cytokines like TNF. Down-regulated following phorbol ester treatment.||SIMILARITY:Belongs to the ZIP transporter (TC 2.A.5) family.

Subcellular localization

Membrane;Multi-pass membrane protein(Potential).

Gene name

solute carrier family 39 (zinc transporter), member 8

Protein sequence

MAPGRAVAGLLLLAAAGLGGVAEGPGLAFSEDVLSVFGAN LSLSAAQLQHLLEQMGAASRVGVPEPGQLHFNQCLTAEE IFSLHGFSNATQITSSKFSVICPAVLQQLNFHPCEDRPK HKTRPSHSEVWGYGFLSVTIINLASLLGLILTPLIKKSY FPKILTFFVGLAIGTLFSNAIFQLIPEAFGFDPKVDSYV EKAVAVFGGFYLLFFFERMLKMLLKTYGQNGHTHFGNDN FGPQEKTHQPKALPAINGVTCYANPAVTEANGHIHFDNV SVVSLQDGKKEPSSCTCLKGPKLSEIGTIAWMITLCDAL HNFIDGLAIGASCTLSLLQGLSTSIAILCEEFPHELGDF VILLNAGMSTRQALLFNFLSACSCYVGLAFGILVGNNFA PNIIFALAGGMFLYISLADMFPEMNDMLREKVTGRKTDF TFFMIQNAGMLTGFTAILLITLYAGEIELE

Database cross reference

RefSeq Protein accession:NP_001128618
RefSeq Protein gi:205830403

Liver relevance

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0031090;C:organelle membrane;IDA:UniProtKB. GO:0005886;C:plasma membrane;TAS:Reactome.

GO-F

GO:0005385;F:zinc ion transmembrane transporter activity;TAS:Reactome.

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr45137

PHOSPHORYLATION

424

T

PhosphoSitePlus

457034

LTP

N

Pathway

Pathway name

IL2

Pathway name

IL4