HuLPr45142

Uniprot ID

S39AE_HUMAN

Uniprot Acc

Q15043;A6NH98;D3DSR4;Q6ZME8;Q96BB3;

Protein name

Zinc transporter ZIP14

Comment

FUNCTION:May be able to transport iron (By similarity). Acts as a zinc-influx transporter.||SUBUNIT:Homotrimer.||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein (Potential). Cell projection, lamellipodium. Note=Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q15043-1; Sequence=Displayed; Name=2; IsoId=Q15043-2; Sequence=VSP 029728; Note=No experimental confirmation available; Name=3; IsoId=Q15043-3; Sequence=VSP 040139;||TISSUE SPECIFICITY:Ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood leukocytes.||SIMILARITY:Belongs to the ZIP transporter (TC 2.A.5) family.||SEQUENCE CAUTION:Sequence=BAA06685.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Subcellular localization

Cell membrane;Multi-pass membrane protein(Potential).Cell projection, lamellipodium.

Gene name

solute carrier family 39 (zinc transporter), member 14

Protein sequence

MKLLLLHPAFQSCLLLTLLGLWRTTPEAHASSLGAPAISA ASFLQDLIHRYGEGDSLTLQQLKALLNHLDVGVGRGNVT QHVQGHRNLSTCFSSGDLFTAHNFSEQSRIGSSELQEFC PTILQQLDSRACTSENQENEENEQTEEGRPSAVEVWGYG LLCVTVISLCSLLGASVVPFMKKTFYKRLLLYFIALAIG TLYSNALFQLIPEAFGFNPLEDYYVSKSAVVFGGFYLFF FTEKILKILLKQKNEHHHGHSHYASESLPSKKDQEEGVM EKLQNGDLDHMIPQHCSSELDGKAPMVDEKVIVGSLSVQ DLQASQSACYWLKGVRYSDIGTLAWMITLSDGLHNFIDG LAIGASFTVSVFQGISTSVAILCEEFPHELGDFVILLNA GMSIQQALFFNFLSACCCYLGLAFGILAGSHFSANWIFA LAGGMFLYISLADMFPEMNEVCQEDERKGSILIPFIIQN LGLLTGFTIMVVLTMYSGQIQIG

Database cross reference

RefSeq Protein accession:NP_001121903
RefSeq Protein gi:190360568

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

GO:0005783;C:endoplasmic reticulum;IDA:HPA. GO:0005794;C:Golgi apparatus;IDA:HPA. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0030027;C:lamellipodium;IEA:UniProtKB-SubCell. GO:0005886;C:plasma membrane;IDA:UniProtKB.

GO-F

GO:0005385;F:zinc ion transmembrane transporter activity;TAS:Reactome.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr45142

ACETYLATION

326

K

PhosphoSitePlus

14321207

LTP

N