HuLPr45155

Uniprot ID

S47A1_HUMAN

Uniprot Acc

Q96FL8;Q53HF5;Q6PD77;Q86VL4;Q9NVA3;

Protein name

Multidrug and toxin extrusion protein 1

Comment

FUNCTION:Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=0.38 mM for TEA; KM=0.10 mM for MPP; KM=0.17 mM for cimetidine; KM=0.78 mM for metformin; KM=2.1 mM for guanidine; KM=1.23 mM for procainamide; KM=0.07 mM for topotecan; KM=0.47 mM for estrone sulfate; KM=2.64 mM for acyclovir; KM=5.12 mM for ganciclovir; Vmax=1.185 nmol/min/mg enzyme toward TEA; Vmax=0.735 nmol/min/mg enzyme toward MPP; Vmax=0.135 nmol/m

Subcellular localization

Cell membrane;Multi-pass membrane protein.

Gene name

solute carrier family 47, member 1

Protein sequence

MEAPEEPAPVRGGPEATLEVRGSRCLRLSAFREELRALLV LAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIA VINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQR SALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTY VTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANL VNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYI LGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCMEW WAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFS VAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSV LLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEAL ACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFA TTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQA QVHANLKVNNVPRSGNSALPQDPLHPGCPENLEGILTND VGKTGEPQSDQQMRQEEPLPEHPQDGAKLSRKQLVLRRG LLLLGVFLILLVGILVRFYVRIQ

Database cross reference

RefSeq Protein accession:NP_060712
RefSeq Protein gi:22907060

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;TAS:Reactome.

GO-F

GO:0015307;F:drug:hydrogen antiporter activity;TAS:Reactome.