Protein basic information
| LiverAtlas Protein ID |
HuLPr45158 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q9Y6R1;C4B714;O15153;Q8NEJ2;Q9H262;Q9NRZ1;Q9UIC0;Q9UIC1;Q9UP50; |
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Protein name |
Electrogenic sodium bicarbonate cotransporter 1 |
|
Comment |
FUNCTION:Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.||ENZYME REGULATION:Inhibited by stilbene derivatives and regulated by cyclic AMP.||SUBUNIT:Interacts with CA2/carbonic anhydrase 2 and CA4/carbonic anhydrase 4 which may regulate transporter activity.||SUBCELLULAR LOCATION:Basolateral cell membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=hcNBC, hhNBC, hNBC1, pNBC, pNCB1, pNBC-1, NBC1b; IsoId=Q9Y6R1-1; Sequence=Displayed; Name=2; Synonyms=hkNBC, hkNBCe1, kNBC, kNBC1, kNBC-1, NBC1a; IsoId=Q9Y6R1-2; Sequence=VSP 016704, VSP 016705; Name=3; IsoId=Q9Y6R1-3; Sequence=VSP 016704, VSP 016705, VSP 016706, VSP 016707; Name=4; IsoId=Q9Y6R1-4; Sequence=VSP 016708; Name=5; IsoId=Q9Y6R1-5; Sequence=VSP 041003;||TISSUE SPE |
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Subcellular localization |
Basolateral cell membrane;Multi-pass membrane protein. |
|
Gene name |
solute carrier family 4, sodium bicarbonate cotransporter, member 4 |
|
Protein sequence
|
MEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYR RRRRHKRKTGHKEKKEKERISENYSDKSDIENADESSSS ILKPLISPAAERIRFILGEEDDSPAPPQLFTELDELLAV DGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHS LFELRTCMEKGSIMLDREASSLPQLVEMIVDHQIETGLL KPELKDKVTYTLLRKHRHQTKKSNLRSLADIGKTVSSAS RMFTNPDNGSPAMTHRNLTSSSLNDISDKPEKDQLKNKF MKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGA LTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEV FHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPAIRI EPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGH GDCEELQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQA LSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGT AVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNN FDYLEFRLWIGLWSAFLCLILVATDASFLVQYFTRFTEE GFSSLISFIFIYDAFKKMIKLADYYPINSNFKVGYNTLF SCTCVPPDPANISISNDTTLAPEYLPTMSSTDMYHNTTF DWAFLSKKECSKYGGNLVGNNCNFVPDITLMSFILFLGT YTSSMALKKFKTSPYFPTTARKLISDFAIILSILIFCVI DALVGVDTPKLIVPSEFKPTSPNRGWFVPPFGENPWWVC LAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYH LDLFWVAILMVICSLMALPWYVAATVISIAHIDSLKMET ETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILK FIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQP DFIYLRHVPLRRVHLFTFLQVLCLALLWILKSTVAAIIF PVMILALVAVRKGMDYLFSQHDLS |
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Database cross reference |
RefSeq Protein accession:NP_001091954
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016323;C:basolateral plasma membrane;IEA:UniProtKB-SubCell. GO:0005887;C:integral to plasma membrane;TAS:ProtInc. |
|
GO-F |
GO:0005452;F:inorganic anion exchanger activity;IEA:InterPro. GO:0005515;F:protein binding;IPI:DFLAT. GO:0008510;F:sodium:bicarbonate symporter activity;TAS:Reactome. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr45158 |
PHOSPHORYLATION |
1026 |
S |
Phospho-ELM |
LTP |
N |
|
|
|
HuLPr45158 |
PHOSPHORYLATION |
1069 |
S |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr45158 |
PHOSPHORYLATION |
1038 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45158 |
PHOSPHORYLATION |
30 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45158 |
PHOSPHORYLATION |
1078 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45158 |
PHOSPHORYLATION |
249 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45158 |
PHOSPHORYLATION |
245 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45158 |
PHOSPHORYLATION |
1026 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr45158 |
PHOSPHORYLATION |
257 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45158 |
PHOSPHORYLATION |
1071 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45158 |
PHOSPHORYLATION |
254 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45158 |
PHOSPHORYLATION |
49 |
T |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr45158 |
PHOSPHORYLATION |
255 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45158 |
PHOSPHORYLATION |
256 |
S |
PhosphoSitePlus |
LTP |
N |
|
