Protein basic information
LiverAtlas Protein ID |
HuLPr45175 |
Uniprot ID |
|
Uniprot Acc |
Q9NP91;A1A4F2;O75590;Q8TF10;Q9NPQ2;Q9NQ77; |
Protein name |
Sodium- and chloride-dependent transporter XTRP3 |
Comment |
FUNCTION:Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids. Involved in the transport of glycine.||SUBCELLULAR LOCATION:Apical cell membrane; Multi-pass membrane protein (By similarity). Note=Located in the apical brush border membrane of kidney proximal tubule cells (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=XT3; IsoId=Q9NP91-1; Sequence=Displayed; Name=2; Synonyms=XT3a; IsoId=Q9NP91-2; Sequence=VSP 050002;||TISSUE SPECIFICITY:Kidney and small intestine. Expressed in the S3 segment of the proximal tubule.||DISEASE:Defects in SLC6A20 are a cause of hyperglycinuria (HG) [MIM:138500]. It is a condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones.||DISEASE:Defects in SLC6A20 are a cause of iminoglycinuria (IG) [MIM:242600]. It is a disorder of renal tubular r |
Subcellular localization |
Apical cell membrane;Multi-pass membrane protein(By similarity). |
Gene name |
solute carrier family 6 (proline IMINO transporter), member 20 |
Protein sequence
|
MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGG GSFLVPYIIMLIVEGMPLLYLELAVGQRMRQGSIGAWRT ISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQ DPLPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNIS PSLQENGGVQWEPALCLLLAWLVVYLCILRGTESTGKVV YFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQL ANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQK HAIIVSLINSFTSIFASIVTFSIYGFKATFNYENCLKKV SLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMF PQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLW SVLYFFMLLMLGIGSMLGNTAAILTPLTDSKIISSHLPK EAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSL LLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVM WAGVSPLLIVSLFVFYLSDYILTGTLKYQAWDASQGQLV TKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRRLKRGDADPVA |
Database cross reference |
RefSeq Protein accession:NP_064593
|
Liver relevance
HLPP validation |
Yes/No |
Yes |
Project name |
French Liver; |
Ontology annotation
GO-C |
GO:0016324;C:apical plasma membrane;ISS:UniProtKB. GO:0005887;C:integral to plasma membrane;IEA:InterPro. |
GO-F |
GO:0015171;F:amino acid transmembrane transporter activity;IDA:UniProtKB. GO:0005328;F:neurotransmitter:sodium symporter activity;IEA:InterPro. |
GO-P |
GO:0034641;P:cellular nitrogen compound metabolic process;TAS:Reactome. GO:0015816;P:glycine transport;IMP:UniProtKB. GO:0015824;P:proline transport;IMP:UniProtKB. |
Pathway
Pathway name |