Protein basic information
| LiverAtlas Protein ID |
HuLPr45232 |
|
Uniprot ID |
|
|
Uniprot Acc |
P82979;A8K393;Q9P066; |
|
Protein name |
SAP domain-containing ribonucleoprotein |
|
Comment |
FUNCTION:Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single- stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis.||SUBUNIT:Interacts with DDX39A. Interacts with FUS.||INTERACTION:Q13838:BAT1; NbExp=1; IntAct=EBI-347495, EBI-348622;||SUBCELLULAR LOCATION:Nucleus.||TISSUE SPECIFICITY:Low expression in spleen, liver, pancreas, testis, thymus, heart, and kidney. Increased levels are seen in hepatocellular carcinoma and pancreatic adenocarcinoma.||INDUCTION:By EPO/erythropoietin.||SIMILARITY:Contains 1 SAP domain.||SEQUENCE CAUTION:Sequence=AAF28994.1; Type=Frameshift; Positions=134, 149;||WEB RESOURCE:Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CIP29ID42967ch12q13.html"; |
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Subcellular localization |
Nucleus. |
|
Gene name |
|
|
Protein sequence
|
MATETVELHKLKLAELKQECLARGLETKGIKQDLIHRLQA YLEEHAEEEANEEDVLGDETEEEETKPIELPVKEEEPPE KTVDVAAEKKVVKITSEIPQTERMQKRAERFNVPVSLES KKAARAARFGISSVPTKGLSSDNKPMVNLDKLKERAQRF GLNVSSISRKSEDDEKLKKRKERFGIVTSSAGTGTTEDT EAKKRKRAERFGIA |
|
Database cross reference |
RefSeq Protein accession:NP_149073
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005634;C:nucleus;NAS:UniProtKB. |
|
GO-F |
GO:0003677;F:DNA binding;IEA:UniProtKB-KW. GO:0005515;F:protein binding;IPI:IntAct. GO:0003723;F:RNA binding;IEA:UniProtKB-KW. |
|
GO-P |
GO:0006355;P:regulation of transcription, DNA-dependent;NAS:UniProtKB. GO:0006417;P:regulation of translation;IEA:UniProtKB-KW. GO:0006351;P:transcription, DNA-dependent;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr45232 |
PHOSPHORYLATION |
162 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr45232 |
PHOSPHORYLATION |
115 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45232 |
PHOSPHORYLATION |
163 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45232 |
ACETYLATION |
142 |
K |
PhosphoSitePlus |
LTP |
N |
|
