HuLPr45238

Uniprot ID

SAST_HUMAN

Uniprot Acc

Q9NV23;Q5VUB6;Q9NUW1;

Protein name

S-acyl fatty acid synthase thioesterase, medium chain

Comment

FUNCTION:In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids (C8 to C2) (By similarity).||CATALYTIC ACTIVITY:Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl- carrier-protein] + oleate.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NV23-1; Sequence=Displayed; Name=2; IsoId=Q9NV23-2; Sequence=VSP 040022;||TISSUE SPECIFICITY:Isoform 2:Up-regulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients.||SIMILARITY:Belongs to the thioesterase family.

Gene name

oleoyl-ACP hydrolase

Protein sequence

MERGDQPKRTRNENIFNCLYKNPEATFKLICFPWMGGGST HFAKWGQDTHDLLEVHSLRLPGRESRVEEPLENDISQLV DEVVCALQPVIQDKPFAFFGHSMGSYIAFRTALGLKENN QPEPLHLFLSSATPVHSKAWHRIPKDDELSEEQISHYLM EFGGTPKHFAEAKEFVKQCSPIIRADLNIVRSCTSNVPS KAVLSCDLTCFVGSEDIAKDMEAWKDVTSGNAKIYQLPG GHFYLLDPANEKLIKNYIIKCLEVSSISNF

Database cross reference

RefSeq Protein accession:NP_001034791
RefSeq Protein gi:89257335

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Liver Organelles;

GO-F

GO:0016295;F:myristoyl-[acyl-carrier-protein] hydrolase activity;IEA:EC. GO:0004320;F:oleoyl-[acyl-carrier-protein] hydrolase activity;IEA:EC. GO:0016296;F:palmitoyl-[acyl-carrier-protein] hydrolase activity;IEA:EC.

GO-P

GO:0006633;P:fatty acid biosynthetic process;IEA:UniProtKB-KW.

Fatty_Acid_Biosynthesis