HuLPr45262

Uniprot ID

SC23B_HUMAN

Uniprot Acc

Q15437;D3DW33;Q503A9;Q5W183;Q9BS15;Q9BSI2;Q9H1D7;

Protein name

Protein transport protein Sec23B

Comment

FUNCTION:Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (By similarity).||SUBUNIT:COPII is composed of at least five proteins:the Sec23/24 complex, the Sec13/31 complex and Sar1 (By similarity).||SUBCELLULAR LOCATION:Golgi apparatus membrane (By similarity). Endoplasmic reticulum membrane (By similarity). Endoplasmic reticulum-Golgi intermediate compartment membrane (By similarity).||DISEASE:Defects in SEC23B are the cause of congenital dyserythropoietic anemia type 2 (CDA2) [MIM:224100]. An autosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, normocytic anemia, iron overload, jaundice, and variable splenomegaly. Ultrastructural features include bi- or multinucleated er

Subcellular localization

Golgi apparatus membrane(By similarity).Endoplasmic reticulum membrane(By similarity).Endoplasmic reticulum-Golgi intermediate compartment membrane(By similarity).

Gene name

Sec23 homolog B (S. cerevisiae)

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLAC LLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYR AKLWACNFCFQRNQFPPAYGGISEVNQPAELMPQFSTIE YVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSL LPPDALVGLITFGRMVQVHELSCEGISKSYVFRGTKDLT AKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPV HKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVALSIAV GLLEGTFPNTGARIMLFTGGPPTQGPGMVVGDELKIPIR SWHDIEKDNARFMKKATKHYEMLANRTAANGHCIDIYAC ALDQTGLLEMKCCANLTGGYMVMGDSFNTSLFKQTFQRI FTKDFNGDFRMAFGATLDVKTSRELKIAGAIGPCVSLNV KGPCVSENELGVGGTSQWKICGLDPTSTLGIYFEVVNQH NTPIPQGGRGAIQFVTHYQHSSTQRRIRVTTIARNWADV QSQLRHIEAAFDQEAAAVLMARLGVFRAESEEGPDVLRW LDRQLIRLCQKFGQYNKEDPTSFRLSDSFSLYPQFMFHL RRSPFLQVFNNSPDESSYYRHHFARQDLTQSLIMIQPIL YSYSFHGPPEPVLLDSSSILADRILLMDTFFQIVIYLGE TIAQWRKAGYQDMPEYENFKHLLQAPLDDAQEILQARFP MPRYINTEHGGSQARFLLSKVNPSQTHNNLYAWGQETGA PILTDDVSLQVFMDHLKKLAVSSAC

Database cross reference

RefSeq Protein accession:NP_001166216
RefSeq Protein gi:289629265

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0030127;C:COPII vesicle coat;IEA:InterPro. GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0033116;C:ER-Golgi intermediate compartment membrane;IEA:UniProtKB-SubCell. GO:0000139;C:Golgi membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0008270;F:zinc ion binding;IEA:InterPro.

GO-P

GO:0006888;P:ER to Golgi vesicle-mediated transport;IEA:InterPro. GO:0006886;P:intracellular protein transport;IEA:InterPro.