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Protein basic information

LiverAtlas Protein ID

HuLPr45294

Uniprot ID

SCAI_HUMAN

Uniprot Acc

Q8N9R8;Q3SXZ1;Q3SXZ2;Q5T163;Q8N1I4;

Protein name

Protein SCAI

Comment

FUNCTION:Tumor suppressor which functions to suppress MKL1- induced SRF transcriptional activity. May function in the RHOA- DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1.||SUBUNIT:Interacts with DIAPH1 (By similarity). Forms a nuclear ternary complex with MKL1 and SRF.||SUBCELLULAR LOCATION:Membrane; Single-pass membrane protein (Potential). Nucleus. Cytoplasm. Note=Nuclear localization is required for inhibition of MKL1 (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N9R8-1; Sequence=Displayed; Name=2; IsoId=Q8N9R8-2; Sequence=VSP 015120;||SIMILARITY:Belongs to the SCAI family.

Subcellular localization

Membrane;Single-pass membrane protein(Potential).Nucleus.Cytoplasm.

Gene name

suppressor of cancer cell invasion

Protein sequence

MVRGARQPQQPRSRLAPRLTGTVEKPPRKRRSRTEFALKE IMSSGGAEDDIPQGERKTVTDFCYLLDKSKQLFNGLRDL PQYGQKQWQSYFGRTFDVYTKLWKFQQQHRQVLDNRYGL KRWQIGEIASKIGQLYYHYYLRTSETSYLNEAFSFYSAI RQRSYYSQVNKEDRPELVVKKLRYYARFIVVCLLLNKMD VVKDLVKELSDEIEDYTHRFNTEDQVEWNLVLQEVAAFI EADPVMVLNDDNTIVITSNRLAETGAPLLEQGMIVGQLS LADALIIGNCNNQVKFSELTVDMFRMLQALEREPMNLAS QMNKPGMQESADKPTRRENPHKYLLYKPTFSQLYTFLAA SFKELPANSVLLIYLSATGVFPTGRSDSEGPYDFGGVLT NSNRDIINGDAIHKRNQSHKEMHCLHPGDLYPFTRKPLF IIVDSSNSVAYKNFTNLFGQPLVCLLSPTAYPKALQDQS QRGSLFTLFLNNPLMAFLFVSGLSSMRRGLWEKCQEYLR KINRDIAQLLTHSRSIDQAFLQFFGDEFLRLLLTRFIFC SATMRMHKIFRETRNYPESYPQLPRDETVENPHLQKHIL ELASILDVRNVFFENTIDDY

Database cross reference

RefSeq Protein accession:NP_001138349
RefSeq Protein gi:221554543

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0005515;F:protein binding;IPI:UniProtKB. GO:0003714;F:transcription corepressor activity;IMP:UniProtKB.

GO-P

GO:0030336;P:negative regulation of cell migration;IMP:UniProtKB. GO:0035024;P:negative regulation of Rho protein signal transduction;ISS:UniProtKB. GO:0006355;P:regulation of transcription, DNA-dependent;IEA:UniProtKB-KW. GO:0006351;P:transcription, DN

Pathway

Pathway name

RhoA_signaling_pathway