Protein basic information
| LiverAtlas Protein ID |
HuLPr45340 |
|
Uniprot ID |
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Uniprot Acc |
P37088;A5X2U9;C5HTZ0;O43271;Q6GSQ6;Q9UM64; |
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Protein name |
Amiloride-sensitive sodium channel subunit alpha |
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Comment |
FUNCTION:Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.||SUBUNIT:Probable heterotrimer containing one alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2.||SUBCELLULAR LOCATION:Apical cell membrane; Multi-pass membrane protein. Note=Apical membrane of epithelial cells.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Alpha ENAC1; IsoId=P37088-1; Sequence=Displayed; Name=2; Synonyms=Alpha ENAC2; IsoId=P37088-2; Sequence=VSP 007719; Name=3; Synonyms=Alpha ENACx; IsoId=P37088-3; Sequence=VSP 007720, VSP 007721; Note=Does not give rise to amiloride-sensitive io |
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Subcellular localization |
Apical cell membrane;Multi-pass membrane protein. |
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Gene name |
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Protein sequence
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MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQ PTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQH NRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNI NLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQT LFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPP PHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSD CFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDT LGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNN SNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVM VHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDY GDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECG CAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHL GCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSR QNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTL LSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLR RFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLS LSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP |
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Database cross reference |
RefSeq Protein accession:NP_001029
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016324;C:apical plasma membrane;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0050699;F:WW domain binding;IPI:BHF-UCL. |
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GO-P |
GO:0007588;P:excretion;TAS:ProtInc. GO:0050896;P:response to stimulus;IEA:UniProtKB-KW. GO:0050909;P:sensory perception of taste;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr45340 |
PHOSPHORYLATION |
663 |
T |
Phospho-ELM |
LTP |
N |
 
|
|
|
HuLPr45340 |
PHOSPHORYLATION |
594 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45340 |
PHOSPHORYLATION |
663 |
T |
PhosphoSitePlus |
LTP |
N |
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Pathway
| Pathway name | |
| Pathway name | |
| Pathway name | |
| Pathway name |
