Protein basic information
| LiverAtlas Protein ID |
HuLPr45444 |
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Uniprot ID |
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Uniprot Acc |
Q9P0V9;B3KRQ9;Q86VP5;Q9HAH6; |
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Protein name |
Septin-10 |
|
Comment |
FUNCTION:Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential).||SUBUNIT:Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity).||SUBCELLULAR LOCATION:Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Note=Using a GFP-fusion protein, detected in the nucleus (PubMed:12711328).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9P0V9-1; Sequence=Displayed; Name=2; IsoId=Q9P0V9-2; Sequence=VSP 014091; Note=Ref.2 (AAH50345) sequence differs from that shown due to a frameshift in position 503; Name=3; IsoId=Q9P0V9-3; Sequence=VSP 041479;||TISSUE SPECIFICITY:Widely expressed. Abundantly expressed in heart and kidney, placenta, skeletal muscles, liver and lung, as well as various tumor cell lines.||SIMILARITY:Belongs to the septin family.||SEQUENCE CAUTION: |
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Subcellular localization |
Cytoplasm.Cytoplasm, cytoskeleton(By similarity). |
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Gene name |
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Protein sequence
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MASSEVARHLLFQSHMATKTTCMSSQGSDDEQIKRENIRS LTMSGHVGFESLPDQLVNRSIQQGFCFNILCVGETGIGK STLIDTLFNTNFEDYESSHFCPNVKLKAQTYELQESNVQ LKLTIVNTVGFGDQINKEESYQPIVDYIDAQFEAYLQEE LKIKRSLFTYHDSRIHVCLYFISPTGHSLKTLDLLTMKN LDSKVNIIPVIAKADTVSKTELQKFKIKLMSELVSNGVQ IYQFPTDDDTIAKVNAAMNGQLPFAVVGSMDEVKVGNKM VKARQYPWGVVQVENENHCDFVKLREMLICTNMEDLREQ THTRHYELYRRCKLEEMGFTDVGPENKPVSVQETYEAKR HEFHGERQRKEEEMKQMFVQRVKEKEAILKEAERELQAK FEHLKRLHQEERMKLEEKRRLLEEEIIAFSKKKATSEIF HSQSFLATGSNLRKDKDRKNSNFL |
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Database cross reference |
RefSeq Protein accession:NP_653311
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0031105;C:septin complex;IEA:InterPro. |
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GO-F |
GO:0005525;F:GTP binding;IEA:UniProtKB-KW. |
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GO-P |
GO:0007049;P:cell cycle;IEA:UniProtKB-KW. GO:0051301;P:cell division;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr45444 |
PHOSPHORYLATION |
25 |
S |
PhosphoSitePlus |
HTP |
N |
 
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