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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr45448

Uniprot ID

SEPP1_HUMAN

Uniprot Acc

P49908;Q6PD59;Q6PI43;Q6PI87;Q6PJF9;

Protein name

Selenoprotein P

Comment

FUNCTION:Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis.||SUBCELLULAR LOCATION:Secreted.||TISSUE SPECIFICITY:Made in the liver and heart and secreted into the plasma. It is also found in the kidney.||PTM:Phosphorylation sites are present in the extracelllular medium.||SIMILARITY:Belongs to the selenoprotein P family.||WEB RESOURCE:Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/sepp1/";

Subcellular localization

Secreted.

Gene name

selenoprotein P, plasma, 1

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MWRSLGLALALCLLPSGGTESQDQSSLCKQPPAWSIRDQD PMLNSNGSVTVVALLQASUYLCILQASKLEDLRVKLKKE GYSNISYIVVNHQGISSRLKYTHLKNKVSEHIPVYQQEE NQTDVWTLLNGSKDDFLIYDRCGRLVYHLGLPFSFLTFP YVEEAIKIAYCEKKCGNCSLTTLKDEDFCKRVSLATVDK TVETPSPHYHHEHHHNHGHQHLGSSELSENQQPGAPNAP THPAPPGLHHHHKHKGQHRQGHPENRDMPASEDLQDLQK KLCRKRCINQLLCKLPTDSELAPRSUCCHCRHLIFEKTG SAITUQCKENLPSLCSUQGLRAEENITESCQURLPPAAU QISQQLIPTEASASURUKNQAKKUEUPSN

Database cross reference

RefSeq Protein accession:NP_001078955
RefSeq Protein gi:148277018

Liver relevance

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005576;C:extracellular region;NAS:UniProtKB.

GO-F

GO:0008430;F:selenium binding;TAS:ProtInc.

GO-P

GO:0006979;P:response to oxidative stress;TAS:ProtInc.

Pathway

Pathway name

TGF_beta_Receptor