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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr45501

Uniprot ID

SFPA2_HUMAN

Uniprot Acc

Q8IWL1;A4QPA7;B2RXI6;B2RXK9;P07714;Q14DV3;Q5RIR8;Q5RIR9;

Protein name

Pulmonary surfactant-associated protein A2

Comment

FUNCTION:In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.||SUBUNIT:Oligomeric complex of 6 set of homotrimers.||SUBCELLULAR LOCATION:Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.||POLYMORPHISM:At least 6 alleles of SFTPA2 are known:1A, 1A(0), 1A(1), 1A(2), 1A(3) and 1A(4). The sequence shown is that of allele 1A(0).||DISEASE:Defects in SFTPA2 are a cause of pulmonary fibrosis idiopathic (IPF) [MIM:178500]. Pulmonary fibrosis is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. It results in acute lung injury with subsequent scarring and endstage lung disease.||MISCELLANEOUS:Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfacta

Subcellular localization

Secreted, extracellular space, extracellular matrix.Secreted, extracellular space, surface film.

Gene name

surfactant protein A2

Protein sequence

MWLCPLALNLILMAASGAACEVKDVCVGSPGIPGTPGSHG LPGRDGRDGVKGDPGPPGPMGPPGETPCPPGNNGLPGAP GVPGERGEKGEAGERGPPGLPAHLDEELQATLHDFRHQI LQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACAR AGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPG DFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWND RNCLYSRLTICEF

Database cross reference

RefSeq Protein accession:NP_001092138
RefSeq Protein gi:148886696

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

Ontology annotation

GO-C

GO:0005581;C:collagen;IEA:UniProtKB-KW. GO:0005615;C:extracellular space;IEA:UniProtKB-SubCell.

GO-F

GO:0005529;F:sugar binding;IEA:UniProtKB-KW.

GO-P

GO:0034329;P:cell junction assembly;TAS:Reactome. GO:0007585;P:respiratory gaseous exchange;IEA:UniProtKB-KW.

Pathway

Pathway name

FOXA1_transcription_factor_network