Protein basic information
| LiverAtlas Protein ID |
HuLPr45508 |
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Uniprot ID |
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Uniprot Acc |
Q96HF1;B3KQR2;O14778;Q9HAP5; |
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Protein name |
Secreted frizzled-related protein 2 |
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Comment |
FUNCTION:Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.||SUBCELLULAR LOCATION:Secreted (By similarity).||TISSUE SPECIFICITY:Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.||DOMAIN:The FZ domain is involved in binding with Wnt ligands (By similarity).||SIMILARITY:Belongs to the secreted frizzled-related protein (sFRP) family.||SIMILARITY:Contains 1 FZ (frizzled) domain.||SIMILARITY:Contains 1 NTR domain. |
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Subcellular localization |
Secreted(By similarity). |
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Gene name |
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Protein sequence
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MLQGPGSLLLLFLASHCCLGSARGLFLFGQPDFSYKRSNC KPIPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAW IPLVMKQCHPDTKKFLCSLFAPVCLDDLDETIQPCHSLC VQVKDRCAPVMSAFGFPWPDMLECDRFPQDNDLCIPLAS SDHLLPATEEAPKVCEACKNKNDDDNDIMETLCKNDFAL KIKVKEITYINRDTKIILETKSKTIYKLNGVSERDLKKS VLWLKDSLQCTCEEMNDINAPYLVMGQKQGGELVITSVK RWQKGQREFKRISRSIRKLQC |
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Database cross reference |
RefSeq Protein accession:NP_003004
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Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;ISS:RefGenome. GO:0031012;C:extracellular matrix;ISS:BHF-UCL. GO:0005615;C:extracellular space;IDA:UniProtKB. GO:0005886;C:plasma membrane;ISS:RefGenome. |
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GO-F |
GO:0001968;F:fibronectin binding;ISS:BHF-UCL. GO:0005178;F:integrin binding;ISS:BHF-UCL. GO:0030165;F:PDZ domain binding;ISS:RefGenome. GO:0048018;F:receptor agonist activity;ISS:BHF-UCL. GO:0016564;F:transcription repressor activity;IDA:UniProtKB. GO |
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GO-P |
GO:0007420;P:brain development;ISS:RefGenome. GO:0003214;P:cardiac left ventricle morphogenesis;IMP:BHF-UCL. GO:0007267;P:cell-cell signaling;ISS:BHF-UCL. GO:0061054;P:dermatome development;ISS:BHF-UCL. GO:0071425;P:hemopoietic stem cell proliferation; |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr45508 |
PHOSPHORYLATION |
289 |
S |
Phospho-ELM |
HTP |
N |
 
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Pathway
| Pathway name |
