Protein basic information
| LiverAtlas Protein ID |
HuLPr45586 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q15464;B9EGM0;D3DRQ5;Q504U5;Q5VUM8; |
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Protein name |
SH2 domain-containing adapter protein B |
|
Comment |
FUNCTION:Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.||SUBUNIT:Interacts with PTPN11 (By similarity). Interacts with phosphorylated 'Tyr-720' of the ligand-activated receptor PDGFRA via its SH2 domain. Interacts with the ligand-activated receptors PDGFRB, FGFR1, KDR/VEGFR2, IL2RB and IL2RG. Interacts with EPS8 and V-SRC. Interacts with GRB2 and GRAP. Interacts with CD3Z. Interacts with tyrosine-phosphorylated LAT upon T-cell antigen receptor activation. Interacts with PLCG1. Interacts with ZAP70, LCP2/SLP-76, VAV1 and GRAP2. Interacts with JAK1 and JAK3. Inte |
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Subcellular localization |
Cytoplasm.Cell membrane;Peripheral membrane protein;Cytoplasmic side. |
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Gene name |
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Protein sequence
|
MAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQP PQAVPQASSAASASCGPATASCFSASSGSLPDDSGSTSD LIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGS GEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSG SPHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGA GDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAG KKDKVTIADDYSDPFDAKNDLKSKAGKGESAGYMEPYEA QRIMTEFQRQESVRSQHKGIQLYDTPYEPEGQSVDSDSE STVSPRLRESKLPQDDDRPADEYDQPWEWNRVTIPALAA QFNGNEKRQSSPSPSRDRRRQLRAPGGGFKPIKHGSPEF CGILGERVDPAVPLEKQIWYHGAISRGDAENLLRLCKEC SYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEKYVLG QNSPPFDSVPEVIHYYTTRKLPIKGAEHLSLLYPVAVRTL |
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Database cross reference |
RefSeq Protein accession:NP_003019
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Chinese Liver; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell. |
|
GO-F |
GO:0005070;F:SH3/SH2 adaptor activity;TAS:ProtInc. |
|
GO-P |
GO:0001525;P:angiogenesis;IEA:UniProtKB-KW. GO:0006915;P:apoptosis;IEA:UniProtKB-KW. GO:0030154;P:cell differentiation;IEA:UniProtKB-KW. GO:0007165;P:signal transduction;TAS:ProtInc. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr45586 |
PHOSPHORYLATION |
246 |
Y |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr45586 |
PHOSPHORYLATION |
312 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr45586 |
PHOSPHORYLATION |
314 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr45586 |
PHOSPHORYLATION |
317 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr45586 |
PHOSPHORYLATION |
388 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr45586 |
PHOSPHORYLATION |
96 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr45586 |
PHOSPHORYLATION |
272 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45586 |
PHOSPHORYLATION |
297 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45586 |
PHOSPHORYLATION |
367 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr45586 |
PHOSPHORYLATION |
485 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45586 |
PHOSPHORYLATION |
247 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45586 |
PHOSPHORYLATION |
312 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr45586 |
PHOSPHORYLATION |
268 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45586 |
PHOSPHORYLATION |
336 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr45586 |
PHOSPHORYLATION |
301 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr45586 |
PHOSPHORYLATION |
317 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr45586 |
PHOSPHORYLATION |
388 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr45586 |
PHOSPHORYLATION |
114 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45586 |
PHOSPHORYLATION |
246 |
Y |
PhosphoSitePlus |
LTP |
N |
|
Pathway
| Pathway name | |
| Pathway name |
