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Protein basic information

LiverAtlas Protein ID

HuLPr45606

Uniprot ID

SHPK_HUMAN

Uniprot Acc

Q9UHJ6;B2R640;Q8WUH3;

Protein name

Sedoheptulokinase

Comment

CATALYTIC ACTIVITY:ATP + sedoheptulose = ADP + sedoheptulose 7- phosphate.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=0.06 mM for sedoheptulose; pH dependence: Optimum pH is 8.5;||SUBCELLULAR LOCATION:Cytoplasm (Potential).||TISSUE SPECIFICITY:Strongly expressed in liver, kidney and pancreas. Expressed at lower levels in placenta and heart. Very weakly expressed in lung and brain.||SIMILARITY:Belongs to the FGGY kinase family.

Subcellular localization

Cytoplasm(Potential).

Gene name

sedoheptulokinase

Protein sequence

MAARPITLGIDLGTTSVKAALLRAAPDDPSGFAVLASCAR AARAEAAVESAVAGPQGREQDVSRILQALHECLAALPRP QLRSVVGIGVSGQMHGVVFWKTGQGCEWTEGGITPVFEP RAVSHLVTWQDGRCSSEFLASLPQPKSHLSVATGFGCAT IFWLLKYRPEFLKSYDAAGTIHDYVVAMLCGLPRPLMSD QNAASWGYFNTQSQSWNVETLRSSGFPVHLLPDIAEPGS VAGRTSHMWFEIPKGTQVGVALGDLQASVYSCMAQRTDA VLNISTSVQLAASMPSGFQPAQTPDPTAPVAYFPYFNRT YLGVAASLNGGNVLATFVHMLVQWMADLGLEVEESTVYS RMIQAAVQQRDTHLTITPTVLGERHLPDQLASVTRISSS DLSLGHVTRALCRGIVQNLHSMLPIQQLQDWGVERVMGS GSALSRNDVLKQEVQRAFPLPMSFGQDVDAAVGAALVMLRRHLNQKES

Database cross reference

RefSeq Protein accession:NP_037408
RefSeq Protein gi:74315356

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0050277;F:sedoheptulokinase activity;IEA:EC.

GO-P

GO:0005975;P:carbohydrate metabolic process;TAS:ProtInc.

Pathway

Pathway name

Inositol_Metabolism