HuLPr45609

Uniprot ID

SHQ1_HUMAN

Uniprot Acc

Q6PI26;Q6MZJ4;Q7Z748;Q9H7E5;Q9NVS8;

Protein name

Protein SHQ1 homolog

Comment

FUNCTION:Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA.||SUBUNIT:Directly interacts with DKC1 alone, but not in the context of the core trimer composed of DKC1, NOP10 and NHP2, nor in the presence of NAF1. Does not interact with NAF1.||SUBCELLULAR LOCATION:Cytoplasm, cytosol. Nucleus, nucleoplasm. Note=May at least partially shuttle between cytosol and nucleoplasm. In the nucleoplasm, exhibits a granular pattern, but is excluded from nucleoli and Cajal bodies. Absent from most H/ACA-box RNA transcription sites.||SIMILARITY:Belongs to the SHQ1 family.||SIMILARITY:Contains 1 CS domain.||SEQUENCE CAUTION:Sequence=BAA91669.1; Type=Frameshift; Positions=79; Sequence=BAB14947.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Subcellular localization

Cytoplasm, cytosol.Nucleus, nucleoplasm.

Gene name

SHQ1 homolog (S. cerevisiae)

Protein sequence

MLTPAFDLSQDPDFLTIAIRVPYARVSEFDVYFEGSDFKF YAKPYFLRLTLPGRIVENGSEQGSYDADKGIFTIRLPKE TPGQHFEGLNMLTALLAPRKSRTAKPLVEEIGASEIPEE VVDDEEFDWEIEQTPCEEVSESALNPQCHYGFGNLRSGV LQRLQDELSDVIDIKDPDFTPAAERRQKRLAAELAKFDP DHYLADFFEDEAIEQILKYNPWWTDKYSKMMAFLEKSQE QENHATLVSFSEEEKYQLRKFVNKSYLLDKRACRQVCYS LIDILLAYCYETRVTEGEKNVESAWNIRKLSPTLCWFET WTNVHDIMVSFGRRVLCYPLYRHFKLVMKAYRDTIKILQ LGKSAVLKCLLDIHKIFQENDPAYILNDLYISDYCVWIQ KVKSKKLAALAEALKEVSLTKAQLGLELEELEAAALLVQ EEETALKAAHSVSGQQTLCSSSEASDSEDSDSSVSSGNE DSGSDSEQDELKDSPSETVSSLQGPFLEESSAFLIVDGG VRRNTAIQESDASQGKPLASSWPLGVSGPLIEELGEQLK TTVQVSEPKGTTAVNRSNIQERDGCQTPNN

Database cross reference

RefSeq Protein accession:NP_060600
RefSeq Protein gi:56550033

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

GO:0005829;C:cytosol;IEA:UniProtKB-SubCell. GO:0005654;C:nucleoplasm;IDA:UniProtKB.

GO-F

GO:0005515;F:protein binding;IPI:UniProtKB.

GO-P

GO:0022618;P:ribonucleoprotein complex assembly;IDA:UniProtKB.