HuLPr45654

Uniprot ID

SIG11_HUMAN

Uniprot Acc

Q96RL6;

Protein name

Sialic acid-binding Ig-like lectin 11

Comment

FUNCTION:Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8- linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.||SUBUNIT:Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96RL6-1; Sequence=Displayed; Name=2; IsoId=Q96RL6-2; Sequence=VSP 008764;||TISSUE SPECIFICITY:Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.||DOMAIN:Contains 1 copy of a cytoplasmic motif that is referred to as

Subcellular localization

Membrane;Single-pass type I membrane protein.

Gene name

sialic acid binding Ig-like lectin 11

Protein sequence

MVPGQAQPQSPEMLLLPLLLPVLGAGSLNKDPSYSLQVQR QVPVPEGLCVIVSCNLSYPRDGWDESTAAYGYWFKGRTS PKTGAPVATNNQSREVEMSTRDRFQLTGDPGKGSCSLVI RDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTK KPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGA ALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRK GVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIY LEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWG PRTLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQ YPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVC VTHSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEH EGEFTCHAQHPLGSQHVSLSLSVHYPPQLLGPSCSWEAE GLHCSCSSQASPAPSLRWWLGEELLEGNSSQGSFEVTPS SAGPWANSSLSLHGGLSSGLRLRCKAWNVHGAQSGSVFQ LLPGKLEHGGGLGLGAALGAGVAALLAFCSCLVVFRVKI CRKEARKRAAAEQDVPSTLGPISQGHQHECSAGSSQDHP PPGAATYTPGKGEEQELHYASLSFQGLRLWEPADQEAPS TTEYSEIKIHTGQPLRGPGFGLQLEREMSGMVPK

Database cross reference

RefSeq Protein accession:NP_001128635
RefSeq Protein gi:205830473

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0005529;F:sugar binding;IEA:UniProtKB-KW.

GO-P

GO:0007155;P:cell adhesion;IEA:UniProtKB-KW.