Protein basic information
| LiverAtlas Protein ID |
HuLPr45714 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q8IVB4;A6NMQ9;Q3LIC2;Q5JPI6;Q5WA58;Q8NAB9; |
|
Protein name |
Sodium/hydrogen exchanger 9 |
|
Comment |
FUNCTION:May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintainance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell.||SUBCELLULAR LOCATION:Late endosome membrane; Multi-pass membrane protein.||TISSUE SPECIFICITY:Ubiquitously expressed in all tissues tested. Expressed at highest levels in heart and skeletal muscle, followed by placenta, kidney, and liver. Expressed in the brain, in the medulla and spinal cord.||DISEASE:Note=A chromosomal aberration involving SLC9A9 has been found in a family with early-onset behavioral/developmental disorder with features of attention deficit-hyperactivity disorder and intellectual disability. Inversion inv(3)(p14:q21). The inversion disrupts DOCK3 and SLC9A9.||DISEASE:Defects in SLC9A9 are a cause of susceptibility to autism type 16 (AUTS16) [MIM:61 |
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Subcellular localization |
Late endosome membrane;Multi-pass membrane protein. |
|
Gene name |
solute carrier family 9 (sodium/hydrogen exchanger), member 9 |
|
Protein sequence
|
MERQSRVMSEKDEYQFQHQGAVELLVFNFLLILTILTIWL FKNHRFRFLHETGGAMVYGLIMGLILRYATAPTDIESGT VYDCVKLTFSPSTLLVNITDQVYEYKYKREISQHNINPH QGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHFFQ NLGSILTYAFLGTAISCIVIGLIMYGFVKAMIHAGQLKN GDFHFTDCLFFGSLMSATDPVTVLAIFHELHVDPDLYTL LFGESVLNDAVAIVLTYSISIYSPKENPNAFDAAAFFQS VGNFLGIFAGSFAMGSAYAIITALLTKFTKLCEFPMLET GLFFLLSWSAFLSAEAAGLTGIVAVLFCGVTQAHYTYNN LSSDSKIRTKQLFEFMNFLAENVIFCYMGLALFTFQNHI FNALFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWN FQHMMMFSGLRGAIAFALAIRNTESQPKQMMFTTTLLLV FFTVWVFGGGTTPMLTWLQIRVGVDLDENLKEDPSSQHQ EANNLDKNMTKAESARLFRMWYSFDHKYLKPILTHSGPP LTTTLPEWCGPISRLLTSPQAYGEQLKEDDVECIVNQDE LAINYQEQASSPCSPPARLGLDQKASPQTPGKENIYEGD LGLGGYELKLEQTLGQSQLN |
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Database cross reference |
RefSeq Protein accession:NP_775924
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0031902;C:late endosome membrane;EXP:Reactome. GO:0055037;C:recycling endosome;IDA:UniProtKB. |
|
GO-F |
GO:0015385;F:sodium:hydrogen antiporter activity;EXP:Reactome. |
|
GO-P |
GO:0006885;P:regulation of pH;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr45714 |
PHOSPHORYLATION |
622 |
Y |
PhosphoSitePlus |
HTP |
N |
 
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