HuLPr45750

Uniprot ID

SLPI_HUMAN

Uniprot Acc

P03973;B2R5H8;P07757;

Protein name

Antileukoproteinase

Comment

FUNCTION:Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues.||SUBCELLULAR LOCATION:Secreted.||TISSUE SPECIFICITY:Mucous fluids.||MISCELLANEOUS:The pathologies of several chronic and acute diseases of the respiratory tract involve an imbalance between the proteases of cells involved in inflammatary responses and the inhibitors of these proteases. The inflammation-mediated release of neutrophil elastase in the lungs of patients whose levels of active alpha-1-antiprotease are compromised by genetic background, cigarette smoking, air pollutants, or a combination of all three can result in severe lung damage and a decreased lifespan. The relatively small size of this protein, its lack of glycosylation and its stability make this protein a candidate for use as a therapeutic agent in diseases mediated by leukocyte elastase- antielastase imbalances.||SIMILA

Subcellular localization

Secreted.

Gene name

secretory leukocyte peptidase inhibitor

Protein sequence

MKSSGLFPFLVLLALGTLAPWAVEGSGKSFKAGVCPPKKS AQCLRYKKPECQSDWQCPGKKRCCPDTCGIKCLDPVDTP NPTRRKPGKCPVTYGQCLMLNPPNFCEMDGQCKRDLKCC MGMCGKSCVSPVKA

Database cross reference

RefSeq Protein accession:NP_003055
RefSeq Protein gi:4507065

GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell.

GO-F

GO:0004867;F:serine-type endopeptidase inhibitor activity;IEA:UniProtKB-KW.

TGF_beta_Receptor

TNFalpha