HuLPr45782

Uniprot ID

SMC6_HUMAN

Uniprot Acc

Q96SB8;A8K8Q6;D6W518;Q05BV4;Q9H0X3;Q9H6M0;

Protein name

Structural maintenance of chromosomes protein 6

Comment

FUNCTION:Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks.||SUBUNIT:Forms a heterodimer with SMC5. Component of the SMC5-SMC6 complex which consists of SMC5, SMC6, NSMCE2/MMS21 and probably NSMCE1.||SUBCELLULAR LOCATION:Nucleus. Chromosome. Note=Associates with chromatin.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96SB8-1; Sequence=Displayed; Name=2; IsoId=Q96SB8-2; Sequence=VSP 022253; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Widely expressed. Overexpressed in testis.||DOMAIN:The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC5, forming a V- shaped heterodimer (By similarity).||PTM:Sumoylated by NSMCE2/MMS21.||

Subcellular localization

Nucleus.Chromosome.

Gene name

structural maintenance of chromosomes 6

Protein sequence

MAKRKEENFSSPKNAKRPRQEELEDFDKDGDEDECKGTTL TAAEVGIIESIHLKNFMCHSMLGPFKFGSNVNFVVGNNG SGKSAVLTALIVGLGGRAVATNRGSSLKGFVKDGQNSAD ISITLRNRGDDAFKASVYGNSILIQQHISIDGSRSYKLK SATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQ FLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKE QIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESL KHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEE QQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKAD VVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEEL KKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQE IEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKEL KDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPL GACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQA LMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPT VLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQ SQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDV DSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELL KRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLE DEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYD AIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEE KQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIE VEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEA RETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCL TLRCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQPGEG NKAAFNDMRALSGGERSFSTVCFI

Database cross reference

RefSeq Protein accession:NP_001135758
RefSeq Protein gi:214010216

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005694;C:chromosome;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW.

GO-P

GO:0006310;P:DNA recombination;IEA:UniProtKB-KW. GO:0006281;P:DNA repair;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr45782

PHOSPHORYLATION

1083

T

PhosphoSitePlus

472537

LTP

HTP

N

HuLPr45782

PHOSPHORYLATION

666

S

PhosphoSitePlus

14161295

LTP

N

HuLPr45782

PHOSPHORYLATION

669

S

PhosphoSitePlus

471749

LTP

N