Protein basic information
| LiverAtlas Protein ID |
HuLPr45795 |
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Uniprot ID |
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Uniprot Acc |
Q96Q15;O43305;Q13284;Q8NFX2;Q96QV0;Q96RW3; |
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Protein name |
Serine/threonine-protein kinase SMG1 |
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Comment |
FUNCTION:Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Acts as part of the SMG1C complex, a mRNA surveillance complex that recognizes and degrades mRNAs containing premature translation termination codons (PTCs). The complex probably acts by associating with ribosomes during tranlation termination on mRNPs. If an exon junction complex (EJC) is located 50-55 or more nucleotides downstream from the termination codon, it phosphorylates UPF1/RENT1, triggering nonsense-mediated decay (NMD). Also acts as a genotoxic stress- activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA dama |
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Subcellular localization |
Nucleus.Cytoplasm. |
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Gene name |
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) |
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Related liver disease name |
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Protein sequence
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MSRRAPGSRLSSGGGGGGTKYPRSWNDWQPRTDSASADPD NLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHAD IQNDEKGGYSVNGGSGENTYGRKSLGQELRVNNVTSPEF TSVQHGSRALATKDMRKSQERSMSYSDESRLSNLLRRIT REDDRDRRLATVKQLKEFIQQPENKLVLVKQLDNILAAV HDVLNESSKLLQELRQEGACCLGLLCASLSYEAEKIFKW IFSKFSSSAKDEVKLLYLCATYKALETVGEKKAFSSVMQ LVMTSLQSILENVDTPELLCKCVKCILLVARCYPHIFST NFRDTVDILVGWHIDHTQKPSLTQQVSGWLQSLEPFWVA DLAFSTTLLGQFLEDMEAYAEDLSHVASGESVDEDVPPP SVSLPKLAALLRVFSTVVRSIGERFSPIRGPPITEAYVT DVLYRVMRCVTAANQVFFSEAVLTAANECVGVLLGSLDP SMTIHCDMVITYGLDQLENCQTCGTDYIISVLNLLTLIV EQINTKLPSSFVEKLFIPSSKLLFLRYHKEKEVVAVAHA VYQAVLSLKNIPVLETAYKLILGEMTCALNNLLHSLQLP EACSEIKHEAFKNHVFNVDNAKFVVIFDLSALTTIGNAK NSLIGMWALSPTVFALLSKNLMIVHSDLAVHFPAIQYAV LYTLYSHCTRHDHFISSSLSSSSPSLFDGAVISTVTTAT KKHFSIILNLLGILLKKDNLNQDTRKLLMTWALEAAVLM KKSETYAPLFSLPSFHKFCKGLLANTLVEDVNICLQACS SLHALSSSLPDDLLQRCVDVCRVQLVHSGTRIRQAFGKL LKSIPLDVVLSNNNHTEIQEISLALRSHMSKAPSNTFHP QDFSDVISFILYGNSHRTGKDNWLERLFYSCQRLDKRDQ STIPRNLLKTDAVLWQWAIWEAAQFTVLSKLRTPLGRAQ DTFQTIEGIIRSLAAHTLNPDQDVSQWTTADNDEGHGNN QLRLVLLLQYLENLEKLMYNAYEG |
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Database cross reference |
RefSeq Protein accession:NP_055907
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
French Liver; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IDA:UniProtKB. GO:0005634;C:nucleus;IDA:UniProtKB. |
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GO-F |
GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW. GO:0005515;F:protein binding;IPI:UniProtKB. GO:0004674;F:protein serine/threonine kinase activity;IDA:UniProtKB. |
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GO-P |
GO:0006281;P:DNA repair;IEA:UniProtKB-KW. GO:0006406;P:mRNA export from nucleus;TAS:UniProtKB. GO:0000184;P:nuclear-transcribed mRNA catabolic process, nonsense- |