Protein basic information
| LiverAtlas Protein ID |
HuLPr45818 |
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Uniprot ID |
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Uniprot Acc |
Q8NHU3;A8K2S9;B2RA61; |
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Protein name |
Phosphatidylcholine:ceramide cholinephosphotransferase 2 |
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Comment |
FUNCTION:Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Required for cell growth.||CATALYTIC ACTIVITY:A ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol.||ENZYME REGULATION:Inhibited by bacterial PC-phospholipase C inhibitor D609.||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Predominantly plasma membrane, some in Golgi apparatus.||TISSUE SPECIFICITY:Brain, heart, kidney, liver, muscle and stomach.||PTM:Palmitoylated on Cy |
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Subcellular localization |
Cell membrane;Multi-pass membrane protein.Golgi apparatus membrane;Multi-pass membrane protein. |
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Gene name |
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Protein sequence
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MDIIETAKLEEHLENQPSDPTNTYARPAEPVEEENKNGNG KPKSLSSGLRKGTKKYPDYIQIAMPTESRNKFPLEWWKT GIAFIYAVFNLVLTTVMITVVHERVPPKELSPPLPDKFF DYIDRVKWAFSVSEINGIILVGLWITQWLFLRYKSIVGR RFCFIIGTLYLYRCITMYVTTLPVPGMHFQCAPKLNGDS QAKVQRILRLISGGGLSITGSHILCGDFLFSGHTVTLTL TYLFIKEYSPRHFWWYHLICWLLSAAGIICILVAHEHYT IDVIIAYYITTRLFWWYHSMANEKNLKVSSQTNFLSRAW WFPIFYFFEKNVQGSIPCCFSWPLSWPPGCFKSSCKKYS RVQKIGEDNEKST |
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Database cross reference |
RefSeq Protein accession:NP_001129729
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Ontology annotation
| GO-C |
GO:0030173;C:integral to Golgi membrane;IDA:UniProtKB. GO:0005887;C:integral to plasma membrane;IDA:UniProtKB. |
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GO-F |
GO:0047493;F:ceramide cholinephosphotransferase activity;IDA:UniProtKB. GO:0016301;F:kinase activity;IEA:UniProtKB-KW. GO:0033188;F:sphingomyelin synthase activity;TAS:Reactome. |
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GO-P |
GO:0006686;P:sphingomyelin biosynthetic process;IDA:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr45818 |
PHOSPHORYLATION |
59 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr45818 |
PHOSPHORYLATION |
24 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45818 |
PHOSPHORYLATION |
56 |
Y |
PhosphoSitePlus |
HTP |
N |
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