HuLPr45866

Uniprot ID

SNR48_HUMAN

Uniprot Acc

Q6IEG0;A8K8P4;Q14C91;Q5T339;Q5THM1;Q5THM2;Q96MK1;

Protein name

U11/U12 small nuclear ribonucleoprotein 48 kDa protein

Comment

FUNCTION:Likely involved in U12-type 5' splice site recognition.||SUBUNIT:Component of the U11/U12 snRNPs that are part of the U12- type spliceosome. Not found in the major spliceosome.||SUBCELLULAR LOCATION:Nucleus.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6IEG0-1; Sequence=Displayed; Name=2; IsoId=Q6IEG0-2; Sequence=VSP 014640, VSP 014641; Note=No experimental confirmation available;||DOMAIN:The CHHC region interacts with the 5' splice site of the U12-type intron.||SIMILARITY:Contains 1 CHHC-type zinc finger.

Subcellular localization

Nucleus.

Gene name

small nuclear ribonucleoprotein 48kDa (U11/U12)

Protein sequence

MEGEPPPVEERRRLQEELNEFVESGCRTLEEVTASLGWDL DSLDPGEEEAAEDEVVICPYDSNHHMPKSSLAKHMASCR LRKMGYTKEEEDEMYNPEFFYENVKIPSITLNKDSQFQI IKQARTAVGKDSDCYNQRIYSSLPVEVPLNHKRFVCDLT QADRLALYDFVVEETKKKRSDSQIIENDSDLFVDLAAKI NQDNSRKSPKSYLEILAEVRDYKRRRQSYRAKNVHITKK SYTEVIRDVINVHMEELSNHWQEEQEKAEDDAEKNEERR SASVDSRQSGGSYLDAECSRHRRDRSRSPHKRKRNKDKD KNCESRRRKERDGERHHSHKRRKQKI

Database cross reference

RefSeq Protein accession:NP_689764
RefSeq Protein gi:71143123

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

GO:0005737;C:cytoplasm;IDA:HPA. GO:0005689;C:U12-type spliceosomal complex;IDA:HGNC.

GO-F

GO:0046872;F:metal ion binding;IEA:UniProtKB-KW.

GO-P

GO:0006397;P:mRNA processing;IEA:UniProtKB-KW. GO:0008380;P:RNA splicing;IC:HGNC.