Protein basic information
| LiverAtlas Protein ID |
HuLPr45884 |
|
Uniprot ID |
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|
Uniprot Acc |
Q9NRS6;Q9NRS5; |
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Protein name |
Sorting nexin-15 |
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Comment |
FUNCTION:May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.||SUBUNIT:Homodimer. Interacts with SNX1, SNX2 and SNX4.||SUBCELLULAR LOCATION:Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NRS6-1; Sequence=Displayed; Name=2; Synonyms=SNX15A; IsoId=Q9NRS6-2; Sequence=VSP 006193;||TISSUE SPECIFICITY:Widely expressed.||DOMAIN:The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate (By similarity).||SIMILARITY:Belongs to the sorting nexin family.||SIMILARITY:Contains 1 MIT domain.||SIMILARITY:Contains 1 PX (phox homology) domain. |
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Subcellular localization |
Cytoplasm.Membrane;Peripheral membrane protein;Cytoplasmic side.Cytoplasmic vesicle membrane;Peripheral membrane protein;Cytoplasmic side. |
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Gene name |
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Protein sequence
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MSRQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKKDP EDVKEVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAF PRAQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQ LKEFFRGGEVTRPLEVSRDLHILPPPLIPTPPPDDPRLS QLLPAERRGLEELEVPVDPPPSSPAQEALDLLFNCESTE EASGSPARGPLTEAELALFDPFSKEEGAAPSPTHVAELA TMEVESARLDQEPWEPGGQEEEEDGEGGPTPAYLSQATE LITQALRDEKAGAYAAALQGYRDGVHVLLQGVPSDPLPA RQEGVKKKAAEYLKRAEEILRLHLSQLPP |
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Database cross reference |
RefSeq Protein accession:NP_037438
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0030659;C:cytoplasmic vesicle membrane;IEA:UniProtKB-SubCell. GO:0005829;C:cytosol;NAS:UniProtKB. |
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GO-F |
GO:0035091;F:phosphatidylinositol binding;IEA:InterPro. GO:0008565;F:protein transporter activity;NAS:UniProtKB. |
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GO-P |
GO:0007154;P:cell communication;IEA:InterPro. GO:0006886;P:intracellular protein transport;NAS:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr45884 |
PHOSPHORYLATION |
148 |
T |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr45884 |
PHOSPHORYLATION |
148 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr45884 |
PHOSPHORYLATION |
227 |
S |
PhosphoSitePlus |
HTP |
N |
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