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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr46081

Uniprot ID

SPON2_HUMAN

Uniprot Acc

Q9BUD6;Q4W5N4;Q9ULW1;

Protein name

Spondin-2

Comment

FUNCTION:Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).||SUBUNIT:Monomer. Interacts with integrin.||SUBCELLULAR LOCATION:Secreted, extracellular space, extracellular matrix (By similarity).||TISSUE SPECIFICITY:Expressed in normal lung tissue but not in lung carcinoma cell lines.||SIMILARITY:Contains 1 spondin domain.||SIMILARITY:Contains 1 TSP type-1 domain.

Subcellular localization

Secreted, extracellular space, extracellular matrix(By similarity).

Gene name

spondin 2, extracellular matrix protein

Protein sequence

MENPSPAAALGKALCALLLATLGAAGQPLGGESICSARAL AKYSITFTGKWSQTAFPKQYPLFRPPAQWSSLLGAAHSS DYSMWRKNQYVSNGLRDFAERGEAWALMKEIEAAGEALQ SVHEVFSAPAVPSGTGQTSAELEVQRRHSLVSFVVRIVP SPDWFVGVDSLDLCDGDRWREQAALDLYPYDAGTDSGFT FSSPNFATIPQDTVTEITSSSPSHPANSFYYPRLKALPP IARVTLVRLRQSPRAFIPPAPVLPSRDNEIVDSASVPET PLDCEVSLWSSWGLCGGHCGRLGTKSRTRYVRVQPANNG SPCPELEEEAECVPDNCV

Database cross reference

RefSeq Protein accession:NP_001121797
RefSeq Protein gi:190341087

Ontology annotation

GO-C

GO:0005578;C:proteinaceous extracellular matrix;IEA:UniProtKB-SubCell.

GO-F

GO:0046872;F:metal ion binding;IEA:UniProtKB-KW.

GO-P

GO:0007411;P:axon guidance;TAS:ProtInc. GO:0007155;P:cell adhesion;IEA:UniProtKB-KW. GO:0045087;P:innate immune response;IEA:UniProtKB-KW.

Pathway

Pathway name

Beta2_integrin_cell_surface_interactions