Protein basic information
| LiverAtlas Protein ID |
HuLPr46095 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q7Z699;B2RPJ8;Q05D53;Q8N256; |
|
Protein name |
Sprouty-related, EVH1 domain-containing protein 1 |
|
Comment |
FUNCTION:Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity).||SUBUNIT:Interacts with Ras (By similarity). Homodimer and heterodimer. Interacts with CAV1. Able to interact with SPRED2 to form heterodimers.||SUBCELLULAR LOCATION:Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Nucleus. Note=Localized in cholesterol-rich membrane raft/caveola fractions.||TISSUE SPECIFICITY:Weakly expressed in embryonic cell line (HEK- 293).||PTM:Phosphorylated on tyrosine (By similarity).||DISEASE:Defects in SPRED1 are the cause of Legius syndrome (LEGIUSS) [MIM:611431]. It is a disorder characterized mainly by cafe au lait macules without neurofibromas or other tumor manifestations of neurofibromatosis type 1, axillary freckling, and macrocephaly. Additional clinical manifestations include Noonan-like facial dysmorphism, lipomas, learning disabilities and att |
|
Subcellular localization |
Cell membrane;Peripheral membrane protein.Membrane, caveola;Peripheral membrane protein.Nucleus. |
|
Gene name |
|
|
Protein sequence
|
MSEETATSDNDNSYARVRAVVMTRDDSSGGWLPLGGSGLS SVTVFKVPHQEENGCADFFIRGERLRDKMVVLECMLKKD LIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRR AIEDISQGCPESKNEAEGADDLQANEEDSSSSLVKDHLF QQETVVTSEPYRSSNIRPSPFEDLNARRVYMQSQANQIT FGQPGLDIQSRSMEYVQRQISKECGSLKSQNRVPLKSIR HVSFQDEDEIVRINPRDILIRRYADYRHPDMWKNDLERD DADSSIQFSKPDSKKSDYLYSCGDETKLSSPKDSVVFKT QPSSLKIKKSKRRKEDGERSRCVYCQERFNHEENVRGKC QDAPDPIKRCIYQVSCMLCAESMLYHCMSDSEGDFSDPC SCDTSDDKFCLRWLALVALSFIVPCMCCYVPLRMCHRCG EACGCCGGKHKAAG |
|
Database cross reference |
RefSeq Protein accession:NP_689807
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
French Liver; |
Ontology annotation
| GO-C |
GO:0005901;C:caveola;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell. |
|
GO-F |
GO:0005173;F:stem cell factor receptor binding;ISS:UniProtKB. |
|
GO-P |
GO:0000188;P:inactivation of MAPK activity;ISS:UniProtKB. GO:0007275;P:multicellular organismal development;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr46095 |
PHOSPHORYLATION |
294 |
Y |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr46095 |
PHOSPHORYLATION |
238 |
S |
PhosphoSitePlus |
HTP |
N |
|
Pathway
| Pathway name |
Signaling_events_mediated_by_Stem_cell_factor_receptor_(c-Kit) |
