Protein basic information
| LiverAtlas Protein ID |
HuLPr46114 |
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Uniprot ID |
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Uniprot Acc |
Q96N96;A2VEA9;A6NF85;B4DQB1;B4DSZ0;B4DVM8;Q5VX68;Q6ZML1;Q8N873;Q8TEK6; |
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Protein name |
Spermatogenesis-associated protein 13 |
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Comment |
FUNCTION:Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up- regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.||ENZYME REGULATION:Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity.||SUBUNIT:Interacts (via ABR and SH3 domain) with APC. The binding of APC enhances its GEF activity by relieving it from an autoinhibitory conformation, in which the ABR and SH3 domains are associated with t |
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Subcellular localization |
Cytoplasm.Cell projection, filopodium.Cell projection, lamellipodium.Cell projection, ruffle membrane. |
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Gene name |
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Protein sequence
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MTSASPEDQNAPVGCPKGARRRRPISVIGGVSLYGTNQTE ELDNLLTQPASRPPMPAHQVPPYKAVSARFRPFTFSQST PIGLDRVGRRRQMRASNVSSDGGTEPSALVDDNGSEEDF SYEDLCQASPRYLQPGGEQLAINELISDGNVVCAEALWD HVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWF PASFVRLRVNQEELSENSSSTPSEEQDEEASQSRHRHCE NKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKHT GMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPH LSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQG KYRHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLA ELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLES IDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQG KSQQRTFFLFDHQLVSCKKDLLRRDMLYYKGRLDMDEME LVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQE DKARWLQACADERRRVQEDKEMGMEISENQKKLAMLNAQ KAGHGKSKGYNRCPVAPPHQGLHPIHQRHITMPTSVPQQ QVFGLAEPKRKSSLFWHTFNRLTPFRK |
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Database cross reference |
RefSeq Protein accession:NP_001159743
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Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IDA:UniProtKB. GO:0030175;C:filopodium;IDA:UniProtKB. GO:0030027;C:lamellipodium;IDA:UniProtKB. GO:0032587;C:ruffle membrane;IDA:UniProtKB. |
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GO-F |
GO:0005515;F:protein binding;IPI:UniProtKB. GO:0030676;F:Rac guanyl-nucleotide exchange factor activity;IDA:UniProtKB. |
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GO-P |
GO:0016477;P:cell migration;IMP:UniProtKB. GO:0046847;P:filopodium assembly;IMP:UniProtKB. GO:0030032;P:lamellipodium assembly;IMP:UniProtKB. GO:0030334;P:regulation of cell migration;IMP:UniProtKB. GO:0035023;P:regulation of Rho protein signal transdu |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr46114 |
PHOSPHORYLATION |
411 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
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HuLPr46114 |
PHOSPHORYLATION |
404 |
Y |
PhosphoSitePlus |
LTP HTP |
N |
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HuLPr46114 |
PHOSPHORYLATION |
26 |
S |
PhosphoSitePlus |
LTP |
N |
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Pathway
| Pathway name | |
| Pathway name |
