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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr46127

Uniprot ID

SPTB2_HUMAN

Uniprot Acc

Q01082;B2RP63;O60837;Q16057;Q53R99;Q59ER3;Q8IX99;

Protein name

Spectrin beta chain, brain 1

Comment

FUNCTION:Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.||SUBUNIT:Like erythrocyte spectrin, the spectrin-like proteins are capable to form dimers which can further associate to tetramers. The short form cannot bind to the axonal protein fodaxin. Interacts with ANK2.||INTERACTION:P02549:SPTA1; NbExp=2; IntAct=EBI-351561, EBI-375617; Q13813:SPTAN1; NbExp=1; IntAct=EBI-351561, EBI-351450;||SUBCELLULAR LOCATION:Cytoplasm, cytoskeleton (By similarity). Cytoplasm, myofibril, sarcomere, M line (By similarity). Note=Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes (By similarity).||SUBCELLULAR LOCATION:Isoform 2:Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=Long; IsoId=Q01082-1; Sequence=Displayed; N

Subcellular localization

Cytoplasm, cytoskeleton(By similarity).Cytoplasm, myofibril, sarcomere, M line(By similarity).

Gene name

spectrin, beta, non-erythrocytic 1

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLF ERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLY TDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDK ALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRF QIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIH NFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQ NAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYY HYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASD LLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEK PPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISD INKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRK AAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIET DIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIR LWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEM KVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRG VNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQ LAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSD DYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGED MIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEE ASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQS LVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDV RGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEAD ACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEM NNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRW SQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTK VIESTQDLGNDLAGVMALQRKLTG

Database cross reference

RefSeq Protein accession:NP_003119
RefSeq Protein gi:112382250

Liver relevance

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Fetal Liver;Human Liver Organelles;French Liver;

Ontology annotation

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GO-C

GO:0005829;C:cytosol;EXP:Reactome. GO:0005730;C:nucleolus;IDA:HGNC. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell. GO:0030017;C:sarcomere;IEA:UniProtKB-SubCell. GO:0008091;C:spectrin;TAS:ProtInc.

GO-F

GO:0003779;F:actin binding;TAS:ProtInc. GO:0005516;F:calmodulin binding;IEA:UniProtKB-KW. GO:0005515;F:protein binding;IPI:IntAct. GO:0005200;F:structural constituent of cytoskeleton;TAS:ProtInc.

GO-P