HuLPr46152

Uniprot ID

SRB4D_HUMAN

Uniprot Acc

Q8WTU2;Q2HIZ5;Q6ZMG3;Q96BF5;

Protein name

Scavenger receptor cysteine-rich domain-containing group B protein

Comment

SUBCELLULAR LOCATION:Secreted (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8WTU2-1; Sequence=Displayed; Name=2; IsoId=Q8WTU2-2; Sequence=VSP 052695, VSP 052696; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay;||INDUCTION:Not induced by a combination of IL1A/interleukin-1 alpha, IL6/interleukin-6 and dexamethasone.||SIMILARITY:Contains 4 SRCR domains.||SEQUENCE CAUTION:Sequence=AAH15651.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=BAD18764.1; Type=Frameshift; Positions=25;

Subcellular localization

Secreted(Potential).

Gene name

scavenger receptor cysteine rich domain containing, group B (4 domains)

Protein sequence

MHKEAEMLIGPQLDEKRWGWRLGDGSAAPPFLPQALSFLL LLPLASALQPTPLPFQELRLVGGPSRCRGRLEVMHGGSW GSVCDDDWDVVDANVVCRQLGCGLALPVPRPLAFGQGRG PILLDNVECRGQEAALSECGSRGWGVHNCFHYEDVAVLC DEFLPTQPPTRKMLTSRAPPTTLPNGKSEGSVRLVGGAN LCQGRVEILHSGLWGTVCDDDWGLPDAAVVCRQLGCGAA MAATTNAFFGYGTGHILLDNVHCEGGEPRLAACQSLGWG VHNCGHHEDAGALCAGLGPPTLTALPSSATREDWAWQTD PSATGVGPQPSRETALLTTAAWAAGKKSGRLRLVGGPGP CRGRVEVLHAGGWGTVCDDDWDFADARVACREAGCGPAL GATGLGHFGYGRGPVLLDNVGCAGTEARLSDCFHLGWGQ HNCGHHEDAGALCAGPEELGLQVQQDGSETTRVPTPRPR DGHLRLVNGAHRCEGRVELYLGQRWGTVCDDAWDLRAAG VLCRQLGCGQALAAPGEAHFGPGRGPILLDNVKCRGEES ALLLCSHIRWDAHNCDHSEDASVLCQPS

Database cross reference

RefSeq Protein accession:NP_542782
RefSeq Protein gi:18152779

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell. GO:0016020;C:membrane;IEA:InterPro.

GO-F

GO:0005044;F:scavenger receptor activity;IEA:InterPro.