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Protein basic information

LiverAtlas Protein ID

HuLPr46196

Uniprot ID

SRSF1_HUMAN

Uniprot Acc

Q07955;B2R6Z7;D3DTZ3;Q13809;

Protein name

Serine/arginine-rich splicing factor 1

Comment

FUNCTION:Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE- dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors.||SUBUNIT:Consists of two polypeptides of p32 and p33. In vitro, self-associates and binds SRSF2, SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with SAFB/SAFB1. Interacts with PSIP1/LEDGF. Interacts with SRPK1. Identified in the spliceosome C complex. Interacts with RSRC1 (via

Subcellular localization

Cytoplasm.Nucleus speckle.

Gene name

serine/arginine-rich splicing factor 1

Protein sequence

MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYG AIRDIDLKNRRGGPPFAFVEFEDPRDAEDAVYGRDGYDY DGYRLRVEFPRSGRGTGRGGGGGGGGGAPRGRYGPPSRR SENRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRDGT GVVEFVRKEDMTYAVRKLDNTKFRSHEGETAYIRVKVDG PRSPSYGRSRSRSRSRSRSRSRSNSRSRSYSPRRSRGSP RYSPRHSRSRSRT

Database cross reference

RefSeq Protein accession:NP_001071634
RefSeq Protein gi:118582269

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0071013;C:catalytic step 2 spliceosome;IDA:UniProtKB. GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0016607;C:nuclear speck;IEA:UniProtKB-SubCell.

GO-F

GO:0000166;F:nucleotide binding;IEA:InterPro. GO:0003723;F:RNA binding;IEA:UniProtKB-KW.

GO-P

GO:0031124;P:mRNA 3'-end processing;TAS:Reactome. GO:0006406;P:mRNA export from nucleus;TAS:Reactome. GO:0006376;P:mRNA splice site selection;TAS:ProtInc. GO:0006369;P:termination of RNA polymerase II transcription;TAS:Reactome.

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr46196

PHOSPHORYLATION

199

S

Phospho-ELM

13475

HTP

yes

HuLPr46196

PHOSPHORYLATION

2

S

Phospho-ELM

13400

HTP

N

HuLPr46196

PHOSPHORYLATION

201

S

Phospho-ELM

13476

HTP

yes

HuLPr46196

PHOSPHORYLATION

205

S

Phospho-ELM

13477

HTP

N

HuLPr46196

PHOSPHORYLATION

231

S

Phospho-ELM

13478

HTP

N

HuLPr46196

PHOSPHORYLATION

234

S

Phospho-ELM

13479

HTP

N

HuLPr46196

PHOSPHORYLATION

238

S

Phospho-ELM

13480

HTP

yes

HuLPr46196

PHOSPHORYLATION

242

S

Phospho-ELM

13481

HTP

N

HuLPr46196

PHOSPHORYLATION

244

S

PhosphoSitePlus

18015557

LTP

N

HuLPr46196

ACETYLATION

179

K

PhosphoSitePlus

11317416

HTP

N

HuLPr46196

MONO-METHYLATION

109

R

PhosphoSitePlus

9291750

LTP

N

HuLPr46196

PHOSPHORYLATION

37

Y

PhosphoSitePlus

464238

HTP

N

HuLPr46196

PHOSPHORYLATION

149

Y

PhosphoSitePlus

464239

HTP

N

HuLPr46196

PHOSPHORYLATION

170

Y

PhosphoSitePlus

464240

HTP

N

HuLPr46196

PHOSPHORYLATION

213

S

PhosphoSitePlus

2303907

LTP

HTP

N

HuLPr46196

PHOSPHORYLATION

215

S

PhosphoSitePlus

2303908

LTP

N

HuLPr46196

PHOSPHORYLATION

217

S

PhosphoSitePlus

2303909

LTP

N

HuLPr46196

PHOSPHORYLATION

207

S

PhosphoSitePlus

2303910

HTP

N

HuLPr46196

PHOSPHORYLATION

209

S

PhosphoSitePlus

2303911

LTP

N

HuLPr46196

PHOSPHORYLATION

211

S

PhosphoSitePlus

2303912

HTP

N

HuLPr46196

PHOSPHORYLATION

219

S

PhosphoSitePlus

2303913

HTP

N

HuLPr46196

PHOSPHORYLATION

225

S

PhosphoSitePlus

2303914

HTP

N

HuLPr46196

PHOSPHORYLATION

227

S

PhosphoSitePlus

2303915

HTP

N

HuLPr46196

PHOSPHORYLATION

223

S

PhosphoSitePlus

2303916

HTP

N

HuLPr46196

PHOSPHORYLATION

221

S

PhosphoSitePlus

2303917

LTP

N

HuLPr46196

PHOSPHORYLATION

237

Y

PhosphoSitePlus

3194558

LTP

yes

HuLPr46196

PHOSPHORYLATION

2

S

PhosphoSitePlus

470471

LTP

N

HuLPr46196

PHOSPHORYLATION

189

Y

PhosphoSitePlus

450580

HTP

N

HuLPr46196

PHOSPHORYLATION

201

S

PhosphoSitePlus

465633

LTP

yes

HuLPr46196

PHOSPHORYLATION

231

S

PhosphoSitePlus

468703

HTP

N

HuLPr46196

PHOSPHORYLATION

234

S

PhosphoSitePlus

468704

LTP

N

HuLPr46196

PHOSPHORYLATION

238

S

PhosphoSitePlus

468705

LTP

yes

HuLPr46196

DI-METHYLATION

97

R

PhosphoSitePlus

476722

HTP

N

HuLPr46196

DI-METHYLATION

109

R

PhosphoSitePlus

476723

HTP

N

HuLPr46196

MONO-METHYLATION

93

R

PhosphoSitePlus

476743

LTP

N

HuLPr46196

ACETYLATION

38

K

PhosphoSitePlus

475784

LTP

N

HuLPr46196

PHOSPHORYLATION

199

S

PhosphoSitePlus

454789

LTP

HTP

yes

HuLPr46196

PHOSPHORYLATION

205

S

PhosphoSitePlus

454790

LTP

N

HuLPr46196

PHOSPHORYLATION

242

S

PhosphoSitePlus

14579931

HTP

N

HuLPr46196

PHOSPHORYLATION

202

Y

PhosphoSitePlus

465891

HTP

yes

HuLPr46196

MONO-METHYLATION

97

R

PhosphoSitePlus

1308911

LTP

HTP

N