Protein basic information
| LiverAtlas Protein ID |
HuLPr46273 |
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Uniprot ID |
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Uniprot Acc |
P51692;Q8WWS8; |
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Protein name |
Signal transducer and activator of transcription 5B |
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Comment |
FUNCTION:Carries out a dual function:signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.||SUBUNIT:Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7.||INTERACTION:Q13287:NMI; NbExp=5; IntAct=EBI-1186119, EBI-372942;||SUBCELLULAR LOCATION:Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocated into the nucleus in response to phosphorylation (By similarity).||DISEASE:Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, and resistance to hexogeneous hormone therapy.||SIMILARITY:Belongs to the transcription factor STAT family.||SIMILARITY:Contains 1 SH2 domain.||WEB RESOU |
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Subcellular localization |
Cytoplasm(By similarity).Nucleus(By similarity). |
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Gene name |
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Related liver disease name |
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Protein sequence
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MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIES QAWDSVDLDNPQENIKATQLLEGLVQELQKKAEHQVGED GFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQR LVREANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQD TENELKKLQQTQEYFIIQYQESLRIQAQFGPLAQLSPQE RLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQK TLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDV LQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEML AEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATV RLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRND YSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRR GAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVI VHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLC EALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLED YSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLK PHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIG GITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLN YLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQ IKQVVPEFVNASADAGGGSATYMDQAPSPAVCPQAHYNM YPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHAQS |
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Database cross reference |
RefSeq Protein accession:NP_036580
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005829;C:cytosol;EXP:Reactome. GO:0005654;C:nucleoplasm;EXP:Reactome. |
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GO-F |
GO:0005509;F:calcium ion binding;IEA:InterPro. GO:0035259;F:glucocorticoid receptor binding;IPI:BHF-UCL. GO:0003700;F:sequence-specific DNA binding transcription factor activity;TAS:ProtInc. |
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GO-P |
GO:0006103;P:2-oxoglutarate metabolic process;ISS:BHF-UCL. GO:0000255;P:allantoin metabolic process;ISS:BHF-UCL. GO:0006101;P:citrate metabolic process;ISS:BHF-UCL. GO:0006600;P:creatine metabolic process;ISS:BHF-UCL. GO:0046449;P:creatinine metabolic |